Objective
Recent studies have noted that dogs are able to identify with high confidence the presence of cancerous tissues in patients at an early stage based on sniffing a breath sample. Because exhaled breath provides non-invasively a continuous window to the biochemical activity within a person, its analysis for medical diagnosis has produced a substantial literature. However, its diagnostic reliability is still incomparable to that of dogs. In fact, breath analysis has not been introduced into common clinical practice yet mainly due to the lack of correlation with high confidence between the presence of certain biomarkers and the illness. Recently, we have shown that widely used commercial atmospheric pressure ionization mass spectrometers (API-MS) can sense breath vapors with molecular masses approaching 450 Da with high signal/background. These findings are in striking contrast with prior breath analysis literature (GC-MS and PTR-MS), involving molecular masses below 290 Da. Our data suggests that dogs have the sensitivity needed to detect such heavy breath vapors, which must be key elements in their cancer recognition process. Urea is one important low volatility biomarker which has not been observed in previous GC-MS and PTR-MS studies, but which we can measure in breath and have been positively identified. In our approach, the subject’s breath is exposed to an electrospray of acidified water, where protonation of polar species takes place near the inlet of an API-MS. The same approach has been successfully used to detect acids (i.e. lactic and pyruvic acids), operating in negative mode. Besides its sensitivity, one main advantage of this approach is that it is on-line and requires no breath sample collection. The main goal of this project is to determine potential biomarkers in breath of breast and lung cancer patients. To do so, we will carry out a systematic survey comparing the breath of healthy subjects and cancer patients.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology lung cancer
- agricultural sciences animal and dairy science domestic animals
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences earth and related environmental sciences atmospheric sciences meteorology atmospheric pressure
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00185 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.