Objective
Neurodegenerative disorders are an increasing healthcare problem. Many of these diseases are characterized by aggregation of proteins, which leads to neuronal dysregulation and cell death. Neurofibrillary tangles, pathological aggregates of tau protein, are the characteristic neuropathological stigmata defining a group of disorders termed Tauopathies. In Frontotemporal Dementias with Parkinsonism linked to Chromosome 17 (FTDP-17), mutations in the tau gene have been identified as cause of the disease. Mice expressing FTDP-17-mutant tau protein develop age-related accumulations of neurofibrillary tangles, behavioural impairments and neuronal cell loss, similar to patients with FTDP-17. When the expression of such mutant tau protein was suppressed by means of a tetracycline-controlled expression system in mice with advanced pathology, cognitive deficits were reversed and neuronal loss was prevented. We therefore propose to study if the small inference RNA (siRNA) technique can be instrumentalized in transgenic mice overexpressing human wild-type or mutant tau (R406/P301S) to suppress tau-gene expression, neuronal cell loss and behavioural deficits. To achieve widespread distribution of siRNA in the brain, a polyethyleneimine delivery system with intracerebroventricular administration will be used, which technique has a good chance to qualify for clinical application. We believe that this project will significantly advance the research in tau-related pathologies.
Fields of science (EuroSciVoc)
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
35037 Marburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.