Objective
The objective of the research project is to understand brain mechanisms of olfactory information processing in the human brain by the way of interdisciplinary approach, involving brain imaging, experimental tools coming from cognitive psychology and clinic al approach. Cerebral imaging techniques such as PET and fMRI are ideal for studying odour processing, and have provided a more comprehensive understanding of human olfaction. We were the first team to investigate olfactory task-related differences in brain activity and to delineate the associated cognitive components of an odour in primary olfactory (piriform) cortex, amygdala, hippocampus orbitofrontal cortex, and insula.
Other recent work by Dr. Gottfried (the proposed outgoing host) and his colleagues has demonstrated that many of these same brain regions are critical to basic olfactory processing, cross-modal olfactory-visual interactions, and odour learning and memory. Despite our advances in understanding the roles of different olfactory areas, current research has been restricted to characterizing the spatial patterns of odour-evoked activation. Recently, with the advent of new computational techniques such as dynamic causal modelling (DCM), it is possible to elucidate the interactions between different brain structures, that is, to characterize at a neuronal level how neural activity within one component of the network changes in relation to other components.
In this project we plan to combine event-related fMRI techniques with DCM to define the neuronal interactions between olfactory regions in healthy subjects. Since patients with mild Alzheimer's disease present an olfactory dysfunction and the host lab has facilities to test them, studies will also be planned in these patients This complementary project will compare the connectivity patterns between patients and healthy elderly controls, to identify where these connections break down, and explain olfactory deficits previously observed in this illness.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- social sciences psychology cognitive psychology
- natural sciences computer and information sciences data science data processing
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.