Objective
How growth in plants is controlled to generate organs with a species-specific size and shape is a fundamental question of developmental biology. The Arabidopsis KLU gene, encoding a putative cytochrome P450, controls the timing of proliferation arrest in growing primordia and thus regulates cell numbers and organ size. KLU acts in a non-cell autonomous manner by producing a mobile growth factor. Its restricted expression pattern at the periphery of organ primordia suggests a model whereby this downstream signal is used to measure the size of the growing primordium and coordinate the arrest of cell proliferation: As the KLU expressing region grows more slowly than the organ as a whole, the downstream signal will be diluted, until it can no longer sustain further proliferation beyond a given primordium size. The proposed research and training programme will focus on three scientific objectives. Firstly, we will test the above model by analyzing in detail the range and dynamics of KLU signalling in growing organs. This will be done using a specific KLU-responsive reporter gene based on the analysis of identified KLU-responsive promoters. Secondly, we will determine whether KLU only acts locally in growing organs or whether its range of action is long enough to be able to coordinate growth throughout the shoot. ‘Genetic grafting’ to combine varying proportions of klu mutant and wild-type tissue in one plant will be used to answer this question. Thirdly, we will screen for mutants in additional genes required to generate, perceive and transduce the KLU-dependent growth signal, using a luciferase-based reporter system. These complementary approaches will provide important insight into the dynamics and molecular mechanism of KLU-dependent signalling in size control. Conceptually, they will underpin detailed comparisons between the mechanisms of size regulation in animals and plants to uncover possible common principles despite different molecular implementations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NR4 7UH Norwich
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.