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Regulating nuclear organisation in telomere maintenance and DNA repair: the role of SUMO modification

Objective

The organisation of the genome into separate domains and sub-compartments through higher order chromatin structure is an important means by which eukaryotic cells control nuclear processes such as DNA transcription and repair. Recent evidence has implicated sumoylation as an important regulator of global nuclear architecture as well as allied processes such as telomere maintenance and DNA damage repair. Using the yeast Saccharomyces cerevisiae as a model organism to look at nuclear dynamics in vivo, we aim to elucidate the mechanism by which SUMO modification regulates these processes.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/dna

Call for proposal

FP7-PEOPLE-2007-2-1-IEF
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Funding Scheme

MC-IEF - Intra-European Fellowships (IEF)
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Coordinator

Novartis Forschungsstiftung
Address
Maulbeerstrasse 66
4058 Basel
Switzerland
Activity type
Research Organisations
EU contribution
€ 179 297,73
Administrative Contact
Susan Gasser (Prof.)