Objectif
The organisation of the genome into separate domains and sub-compartments through higher order chromatin structure is an important means by which eukaryotic cells control nuclear processes such as DNA transcription and repair. Recent evidence has implicated sumoylation as an important regulator of global nuclear architecture as well as allied processes such as telomere maintenance and DNA damage repair. Using the yeast Saccharomyces cerevisiae as a model organism to look at nuclear dynamics in vivo, we aim to elucidate the mechanism by which SUMO modification regulates these processes.
Champ scientifique
Mots‑clés
Thème(s)
Appel à propositions
FP7-PEOPLE-2007-2-1-IEF
Voir d’autres projets de cet appel
Régime de financement
MC-IEF - Intra-European Fellowships (IEF)Coordinateur
4058 BASEL
Suisse