Objective Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to several diseases with a huge social impact, ranging from autoimmune diseases to septic shock and cancer. While the requirement for specific transcription factors (TF) in inflammatory gene transcription is known, quantitative models describing how their interactions with genomic sequences leads to normal or pathological outcomes are not available. Unravelling how genomic organization underlies the orchestrated expression of inflammatory genes is crucial to understand how to pharmacologically tune pathological inflammatory responses. Now is the right moment to tackle this question as for the first time we have genomic technologies and computational abilities to generate the necessary quantitative data and to build computational models describing spatiotemporal coordination of transcription of hundreds of inflammatory genes by multiple TFs. To implement this objective, we have assembled a consortium of top-level scientists in the European Research Area who reached documented excellence in complementary aspects of transcriptional control, namely quantitative measurement of TF-DNA interactions, in vitro and in vivo analysis of chromatin organization, manipulation of genomic sequences by homologous recombination, computational and systems biology applied to transcriptional circuits. The network provides the critical mass required to generate ample quantitative and complementary datasets describing the minimal transcriptional regulatory blocks relevant for inflammation, thus enabling the integration of their coordinated activities via systems approaches. Each research group complements the other participants and the whole projects, and as such this proposal can not be carried out on any individual level. Fields of science natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesclinical medicineoncologynatural sciencesmathematicsapplied mathematicsmathematical model Keywords inflammation multidisciplinary approaches quantitative data system modelling Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.1.2-5 - Multidisciplinary fundamental genomics and molecular biology approaches to study basic biological processes relevant to health and diseases Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Address Wellington square university offices OX1 2JD Oxford United Kingdom See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Sue Stoneham (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 485 877,45 Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Participation ended United Kingdom EU contribution € 331 011,55 Address South kensington campus exhibition road SW7 2AZ London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Julie Williams (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE JOSEPH FOURIER GRENOBLE 1 France EU contribution € 208 800,00 Address Avenue centrale, domaine universitaire 621 38041 Grenoble See on map Activity type Higher or Secondary Education Establishments Administrative Contact Leslie Hollett (Ms.) Links Contact the organisation Opens in new window Website Opens in new window ECOLE NORMALE SUPERIEURE DE LYON France EU contribution € 316 800,00 Address 46 allee d'italie 69364 Lyon See on map Activity type Higher or Secondary Education Establishments Administrative Contact Valerie Tessier (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA VITA-SALUTE SAN RAFFAELE Italy EU contribution € 280 800,00 Address Via olgettina 58 20132 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Raffaella Voltolini (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ISTITUTO EUROPEO DI ONCOLOGIA SRL Italy EU contribution € 242 400,00 Address Via filodrammatici 10 20121 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ilaria Foti (Ms.) Links Contact the organisation Opens in new window Website Opens in new window WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution € 166 380,00 Address Herzl street 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Administrative Contact Talia Tzahor (Ms.) Links Contact the organisation Opens in new window Website Opens in new window THE HEBREW UNIVERSITY OF JERUSALEM Israel EU contribution € 193 500,00 Address Edmond j safra campus givat ram 91904 Jerusalem See on map Activity type Higher or Secondary Education Establishments Administrative Contact Eran Vardi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAT ZU KOLN Germany EU contribution € 349 200,00 Address Albertus magnus platz 50931 Koln See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Petra Schreiner-Kaub (Ms.) Links Contact the organisation Opens in new window Website Opens in new window OXFORD NANOPORE TECHNOLOGIES LTD United Kingdom EU contribution € 90 000,00 Address Robert robinson avenue - oxford science park 4 OX4 4GA Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jim Bruce (Dr.) Links Contact the organisation Opens in new window IC CONSULTANTS LTD United Kingdom EU contribution € 261 536,00 Address Sherfield building, imperial college of science, technology and medicine SW7 2AZ London See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michiyo Shima (Ms.) Links Contact the organisation Opens in new window Website Opens in new window
