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From Sequence to Consequence - Tools for the Exploitation of Livestock Genomes

Objective

QUANTOMICS will deliver a step-change in the availability of cutting edge technologies and tools for the economic exploitation of livestock genomes. We will provide the tools to identify rapidly the causative DNA variation underpinning sustainability in livestock and for industry to exploit high-density genomic information. Our adaptable quantitative and genomic tools each based on cutting-edge technologies and valuable in itself, will together form a powerful integrated pipeline with wide application. To deliver these outcomes we will; i) use comparative genomics to annotate putatively functional features of the genomes of the EU’s key farmed animal livestock species; ii) enhance existing molecular genetic tools (to include copy number variation, CNV); iii) deliver computationally optimised tools for genome-wide selection (GWS) to include CNV; iv) apply these tools to important health and welfare traits in commercial populations of dairy cattle and broiler chickens, determining the benefits and constraints; v) use hyper-parallel resequencing of DNA within identified genomic features underlying loci of large effect in significant numbers of animals to catalogue variation; vi) develop new visualisation tools to make this variation publicly available via the Ensembl genome-browser; vii) develop tools to prioritise the likely functionality of identified polymorphisms; viii) validate the utility of the putative causative haplotypes within commercial populations; ix) test the potential advances from combined GWS and gene assisted selection in breeding programmes; x) explore new methods to manage molecular biodiversity; xi) assess the implications of these new tools for breeding programme design, and xii) disseminate results of the project achieving major competitive, animal health and welfare impacts across the EU livestock industry and ultimately consumers. QUANTOMICS will have wide application in all farmed species and leave a legacy of resources for future research.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

FP7-KBBE-2007-2A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

BIOSCIENCE NETWORK LIMITED
Address
Easter Bush
EH25 9RG Roslin
United Kingdom
Activity type
Research Organisations
EU contribution
€ 281 750
Administrative Contact
Christopher Charles Warkup (Mr.)

Participants (17)

DANSK SVINEPRODUKTION

Participation ended

Denmark
Address
Axeltorv 3
1609 Copenhagen
Activity type
Research Organisations
Administrative Contact
Ingela Hedebro Velander (Dr.)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 954 430
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Niels Kiil (Mr.)
NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET
Norway
EU contribution
€ 396 495,20
Address
Universitetstunet 3
1433 As
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Olav Aasbo (Mr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 499 800
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Barbara Baron (Ms.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 1 089 695
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
UNIVERSIDAD AUTONOMA DE BARCELONA
Spain
EU contribution
€ 122 000
Address
Calle Campus Universitario Sn Cerdanyola V
08290 Cerdanyola Del Valles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Armand Sanchez Bonastre (Prof.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 1 193 250
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alessandro Bagnato (Prof.)
MAA JA ELINTARVIKETALOUDEN TUTKIMUSKESKUS
Finland
EU contribution
€ 300 600
Address
Building O - Humppilantie 14
FI-31600 Jokioinen
Activity type
Research Organisations
Administrative Contact
Johanna Vilkki (Dr.)
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 383 000
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Stadler (Prof.)
AVIAGEN LIMITED
United Kingdom
EU contribution
€ 99 600
Address
Stratford Hatchery Alscott Industrial Estate, Atherstone On Stour
CV37 8BH Stratford-upon-avon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kellie Watson (Dr.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 242 200
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eran Vardi (Dr.)
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
EU contribution
€ 157 350
Address
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Georgia Petridou (Ms.)
ARGENTIX LIMITED
United Kingdom
EU contribution
€ 47 000
Address
Wallace Building Roslin Biocentre
EH25 9PS Midlothian
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christopher Harris (Mr.)
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 232 500,80
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Marta Balza (Ms.)
LANDBRUG & FODEVARER F.M.B.A.
Denmark
Address
Axeltorv 3
1609 Kobenhavn V
Activity type
Research Organisations
Administrative Contact
Ingela Hedebro Velander (Dr.)
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
Australia
Address
Clunies Ross Street Csiro Black Mountain Science And Innovation Park
2601 Acton Act
Activity type
Research Organisations
Administrative Contact
Brian Dalrymple (Dr.)
Associazione Nazionale Allevatori bovini della Razza Bruna
Italy
Address
Loc. Ferlina 204
37012 Bussolengo (Vr)
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Enrico Santus (Dr.)