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CONtrol of COmmunity-acquired MRSA: Rationale and Development of counteractions

Objective

Until recently, methicillin-resistant Staphylococcus aureus (MRSA) were confined to hospitals (HA-MRSA). However, community- and farm-associated MRSA (CA-and FA-MRSA) has developed as an important cause of infections. No strategies exist to combat these MRSA. CONCORD is aimed at explaining the ecological success in the community and the farm environment of CA- and FA-MRSA in contrast to HA-MRSA in order to facilitate the rationale and development of effective strategies against CA- and FA-MRSA. Epidemiology of CA-MRSA is complex and incomplete. To obtain both a more complete description of the epidemiology of CA-MRSA and recent isolates small scale surveillance will be performed among patients in the 20 most populous EU countries, pig farms in major pig exporting countries and important veal calve raising countries. Genomics data for CA-MRSA are limited and non-existent for FA-MRSA. Successful adaptation of MRSA to a new environment supposes either the acquisition of novel properties or the differential expression of genes already present. Only 2 CA-MRSA have been fully sequenced and the UMCU has sequenced a FA-MRSA. Whole genome sequencing, comparative genome hybridization and transcriptomics will be used to understand the genetic adaptations of MRSA in the community. The contribution of putative virulence factors to pathogenicity will be studied by knock-outs and complemented strains of these knock-outs. The strains will be tested in in vitro and ex vivo models to establish their physiological role. Mathematical modelling is an important tool to manage infection control. A few models exist that evaluate measures to reduce transmission of HA-MRSA or CA-MRSA in jails. No models are available for FA-MRSA. Modelling will provide both fundamental insights on MRSA epidemiology as well as specific recommendations or testable hypotheses for human and veterinary clinical practice. The potential of intervention strategies to combat CA- and FA-MRSA will be determined.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome
  • /medical and health sciences/health sciences/epidemiology

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 679 471
Administrative Contact
Susan Zwaagstra (Dr.)

Participants (8)

UNIVERSITE LYON 1 CLAUDE BERNARD
France
EU contribution
€ 226 800
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Javier Olaiz (Dr.)
INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA
Portugal
EU contribution
€ 202 512
Address
Avenida Da Republica, Estacao Agronomica Nacional
2784-505 Oeiras
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margarida Martinez (Dr.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 225 000
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
J.A. Manders (Dr.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 311 308
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
National Medicines Institute (Narodowy Instytut Lekow)
Poland
EU contribution
€ 235 200
Address
Chelmska
00-725 Warsaw
Activity type
Research Organisations
Administrative Contact
Renata Cellmer (Ms.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 353 092
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Dyrsting (Prof.)
UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 525 257
Address
Spui 21
1012WX Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Floyd R.A. Wittink (Dr.)
NOVOLYTICS LIMITED
United Kingdom
EU contribution
€ 235 552
Address
Baclays Venture Centre Unit 26
CV4 7EZ Coventry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sandy Primrose (Mr.)