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High yield and performance stem cell lab

Objective

The success of stem cell therapy is highly dependent on a safe and reliable supply of human stem cells and stem cell-derived differentiated cells, which must be assured by efficient and robust culture methods. Current culture of human embryonic and adult stem cells is not optimised (with regards to e.g. media, growth factors, supporting biomaterials, differentiation techniques) and is far from fulfilling the demands in terms of reproducibility and preciseness. Additionally, current methods do not allow fast screening of culture conditions for their systematic optimisation. These limitations currently slow down the development of stem cell applications and will be addressed and overcome by the Hyperlab project. To reach the overall aim of developing new and improved culture methods, media and protocols for stem cell cultivation and differentiation, Hyperlab will adapt novel microfluidics-based cell cultivation technologies to the specific needs of stem cell culture. The developed culture systems will have two major advantages over existing approaches: on the one hand, they will improve stem cell culture in terms of microenvironment control, reproducibility, robustness and efficiency. On the other hand, these microscale technologies, together with developed transgenic readout systems, will allow medium to high throughput screening of culture conditions, enabling determination of optimal protocols in shorter time. Once established, technologies, protocols and conditions will be evaluated for their upscalability and will be made GMP-compliant to form a solid basis for progress in human stem cell therapy. To implement this innovative strategy, Hyperlab follows an integrated approach, bringing together renowned experts from stem cell biology, microsystem technologies, biomaterial design and relevant regulatory bodies. Hyperlab is thus in a position to provide standardised, reproducible methods and tools to advance therapeutic stem cell research.

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Address
Hansastrasse 27C
80686 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 409 610,47
Administrative Contact
Andrea Zeumann (Ms.)

Participants (8)

INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA
Portugal
EU contribution
€ 400 200
Address
Avenida Da Republica Quinta Do Marques
2781-901 Oeiras
Activity type
Research Organisations
Administrative Contact
Elsa Vieira (Ms.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 460 182
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jutta Landvogt (Ms.)
Institut für Bioprozess- und Analysenmesstechnik e.V.
Germany
EU contribution
€ 432 644
Address
Rosenhof 1
37308 Heilbad Heiligenstadt
Activity type
Research Organisations
Administrative Contact
Manfred Meister (Mr.)
CRYO-SAVE GROUP NV

Participation ended

Netherlands
EU contribution
€ 202 722,53
Address
Ijsselkade 8
7201 hb Zutphen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gilbert Verhoef (Mr.)
Takara Bio Europe AB
Sweden
EU contribution
€ 362 575
Address
Arvid Wallgrens Backe
413 46 Göteborg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jenny Goodwin (Ms.)
UNIVERSIDAD CATOLICA DEL NORTE
Chile
EU contribution
€ 101 376
Address
Avenida Angamos 0610
Antofagasta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Luis Moncayo (Mr.)
ARTTIC
France
EU contribution
€ 221 046
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eric Papon (Dr.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 397 245
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Wolf Husslein (Prof.)