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The identification, characterisation and exploitation of novel Gram-negative drug targets

Objective

An ambitious long-term programme of multidisciplinary research with two closely linked objectives is proposed to support antimicrobial drug development. Firstly, to advance understanding, at the molecular level, of fundamental and important aspects of the biology of Gram-negative bacteria using the important pathogen model Pseudomonas aeruginosa. Secondly, and most important, to exploit our discoveries and develop ligands and inhibitors (hit and lead compounds) with the potential to underpin the discovery of improved therapies for Gram-negative infections. The research covers five distinct areas, or work packages. (WPI) The experimental validation and therefore identification of novel targets by gene knockout in P. aeruginosa. (WPII) Cloning, characterisation, biochemical and structural biology, of the novel targets. (WPIII) A directed, search for ligands/inhibitors, exploiting data from WPI and WPII, for these validated antimicrobial drug targets by virtual screening (VS) and assessment of druggabilty, high-throughput screening (HTS) of a carefully prioritised subset of targets. (WPIV) The characterisation of the interactions formed between the drug target and the ligand/inhibitor by biochemical and crystallographic study, computational modelling and then design and modelling to enhance binding properties. (WPV) The initial biological testing for efficacy against Gram-negative bacteria.

Call for proposal

FP7-HEALTH-2007-B
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Coordinator

UNIVERSITY OF DUNDEE
Address
Nethergate
DD1 4HN Dundee
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 545 279
Administrative Contact
Zoe Kidd (Ms.)

Participants (4)

LIONEX GMBH
Germany
EU contribution
€ 639 003
Address
Salzdahlumer Strasse 196
38126 Braunschweig
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mahavir Singh (Prof.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 887 614
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jill Blomstrand (Ms.)
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
United Kingdom
EU contribution
€ 1 064 967
Address
North Street 66 College Gate
KY16 9AJ St Andrews
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fiona Thomson (Ms.)
Mfd-diagnostics GmbH
Germany
EU contribution
€ 454 600
Address
Mikroforum Ring 2
55234 Wendelsheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bernd Lecher (Dr.)