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Genetic study of Common Hereditary Bowel Cancers in Hispania and the Americas

Objectif

Colorectal cancer (CRC) is common in both sexes, has relatively poor outcome and has no major avoidable risk factor. Recent studies have shown that common inherited single nucleotide polymorphisms (SNPs) can increase cancer risk. We have shown CRC risk to be associated with SNPs on chromosomes 8q24.21 15q14 and 8q21. These variants account for <5% of the genetic risk of CRC, but will be very important when their effects are added to those of other, as-yet undetected CRC SNPs. A few genome-wide association studies (GWASs) based on populations of European descent are trying to identify the remaining common CRC genes. Evidence suggests that these studies will not be large enough on their own to detect all CRC SNPs, as: relative risks associated with most SNPs are modest; some disease alleles are rare, at least in Europe; and many variants may lie outside conventional gene boundaries or haplotype blocks. The admixed LA population provides an exciting opportunity to identify new CRC genes that are more tractable to detection in LA, or have been missed by chance in European studies. We shall undertake a combined GWAS and admixture mapping study for CRC predisposition genes in 6,000 LA cases and 6,000 controls. We shall test the disease-associated variants in 3,500 cases and 3,500 controls from Europe. We aim primarily to detect SNPs with effects in both LA and Europe, but also SNPs with effects specific to LA. Eventually, we aim to develop a polymorphism panel for predicting the risk of CRC in the general population, so that those at increased risk can be offered effective measures to prevent cancer. CRC is increasing in frequency in LA and prognosis is poorer than in Europe. We shall use our project as a focus for education about CRC, especially in LA. The study will also provide training for young LA researchers. Our work will provide a direct benefit to medical science and the populations of LA and Europe.

Appel à propositions

FP7-HEALTH-2007-B
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Coordinateur

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Adresse
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Linda Pialek (Ms.)
Contribution de l’UE
€ 1 624 680,38

Participants (9)

Universidad del Tolima
Colombie
Contribution de l’UE
€ 274 800
Adresse
Altos De Santa Helena
AA546 Ibague

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
John Jairo Mendez Arteaga (Dr.)
Universidad Autonoma de Nuevo Leon
Mexique
Contribution de l’UE
€ 165 600
Adresse
Av. Universidad S/n
66428 San Nicolas De Los Garza

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Nora Luisa Salas De La Rosa (Ms.)
FUNDACAO ANTONIO PRUDENTE
Brésil
Contribution de l’UE
€ 165 600
Adresse
Rua Prof Antonio Prudente 211
01509010 Sao Paulo

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Type d’activité
Research Organisations
Contact administratif
Benedito Rossi (Dr.)
FUNDACION DE INVESTIGACIONES GENOMICAS

Participation terminée

Argentine
Contribution de l’UE
€ 247,62
Adresse
Yerbal 2365 Pb G-h
C1406GKA Buenos Aires
Type d’activité
Research Organisations
Contact administratif
Carlos Diego Cid (Mr.)
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Espagne
Contribution de l’UE
€ 540 800
Adresse
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Fernando Sedano Arnaez (Dr.)
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Espagne
Contribution de l’UE
€ 63 360
Adresse
Carrer Rossello 149
08036 Barcelona

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Type d’activité
Research Organisations
Contact administratif
Emili Bargallo (Mr.)
INSTITUTO PORTUGUES DE ONCOLOGIA DO PORTO FRANCISCO GENTIL, EPE
Portugal
Contribution de l’UE
€ 58 800
Adresse
Rua Antonio Bernardino Almeida
4200-072 Porto

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Type d’activité
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contact administratif
Ana Celeste Costa Strecht Monteiro (Dr.)
UNIVERSIDAD DE LA REPUBLICA
Uruguay
Contribution de l’UE
€ 80 400
Adresse
Avenida 18 De Julio 1824
11200 Montevideo

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Elizabeth Prendez (Ms.)
KBiosciences ltd

Participation terminée

United Kingdom
Adresse
Unit 7 Maple Park Essex Road
EN110EX Hoddesdon
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Philip Robinson (Mr.)