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Content archived on 2024-05-29

Molecular analysis of His-domain protein tyrosine phosphatase, a putative tumour suppressor


This project addresses a research topic relevant to the field of life sciences, genomics and biotechnology for health in FP6. Protein tyrosine phosphorylation is a key mechanism for signal transduction and the regulation of a broad set of physiological pro cesses that are characteristic to multi-cellular organisms. Recently the entire repertoire of the human protein tyrosine phosphatase (PTP) genes has been discovered. From the few studies on PTPs it is becoming apparent that PTPs tend to be very specific and to have non-redundant unique functions. Therefore, it is essential to understand the physiological functions of the individual PTPs. One of the newly discovered PTPs is the Histidine domain protein tyrosine phosphatase (HD-PTP), which has been suggested t o be a tumour suppressor. This project attempts to investigate through a multidisciplinary approach the physiological role of this PTP.

Several objectives are proposed:
i) to find the physiological relevant proteins that interact with HD-PTP and and their importance for cell physiology;
ii) to understand the role of HD-PTP structural domains for its function;
iii) to investigate the role of HD-PTP in vertebrate development.

The project is planned to be accomplished in 3 years being performed by a small team of researchers including the applicant. The project is expected to be an opportunity for the applicant to put into practice her scientific knowledge she gained in the USA, the country where she spent the last 10 years and to help the applicant receive a s table position as a researcher in her home country, thus, contributing to the reversing and cancelling the effects of the European brain drain to third countries. At the same time, the project will allow the applicant and the host institution to develop lasting co-operation with scientists from the USA.

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EU contribution
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Spl. Independentei 296

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