Objective
In teeth sequential and reciprocal interactions between epithelium and ectomesenchyme play a pivotal role in their development. A progress has been made in identifying various key transcription factors and signalling molecules participating in epithelial–mesenchymal signalling, involving different pleiotropic morphogens, such as bone morphogenetic proteins, fibroblast growth factors, hedgehog and Wnt proteins as well, which are responsible for patterning, morphogenesis and differentiation. There is a growing interest in different stem cell niches located in tooth germs and how they provide cues for the maintenance, proliferation and differentiation of dental cells. The rodent incisor has a unique property: it exhibits asymmetric growth and enamel distribution due to the presence of discrete stem cell compartments at the apical part. The main research goal is to identify different key signalling molecules that regulate stem cell proliferation in the rodent incisor epithelial stem cell niche. As a former MC EIF fellow, I learned the details of in situ hybridization, tissue culture plus bead implantation assays, cell proliferation analyzes combined with different imaging techniques, digital densitometry, therefore we are planning to analyze mouse tooth development using all of these techniques to elucidate how the spatial and temporal expression pattern of these signalling molecules affects epithelial stem cell nice of incisor development. Additionally our aim is to characterize the stem cells molecularly and to develop methods for their isolation. We hope that our findings will have significant implications for organ regeneration and should prove of great interest to scientists in the fields of biology, medicine. The long-lasting benefit of my ERG is to adaptate these molecular morphological techniques at my host institution. The instrumental and scientific background is avaiable at host available, therefore it is possible to properly carry out the studies proposed.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences medical biotechnology cells technologies stem cells
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-2-ERG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4032 Debrecen
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.