Objective
Vernalization is the acquisition or acceleration of the ability to flower by chilling treatment. After a prolonged cold treatment, like winter, vernalized plants have the competence to flower, and this competence is "remembered" during the development of the plant. The molecular basis of this cellular memory is the regulation of the floral repressor FLOWERING LOCUS C (FLC) by the vernalization pathway. FLC mRNA levels decrease during the prolonged cold and this repression is maintained during subsequent development allowing the plant to respond to floral promotive signals.
The vernalization signal is mitotically stable, but at some point during gamete formation or seed development, FLC mRNA levels are reset to a high level to ensure the next generation also needs vernalization before flowering. The purpose of this work is to characterize at the molecular level the precise sequence of events mediating the epigenetic regulation of FLC. This includes a detailed study of the histone modifications (deacetylati ons, methylations, ubiquitinations and phosphorylations) that govern FLC expression; how these chromatin modifications are maintained; and how these epigenetic marks are reset during seed development.
Vernalization provides a rare example of a system where the temporal changes in gene expression are slow enough to be able to realistically describe the fully sequence of events. Personally speaking, this study should provide important information relevant to the study of epigenetic regulation in all life kingdoms and introduces me to a new research area that will provide me a wider perspective of my scientific career.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.