Objective
Breast cancer is the most common cancer in women and, after lung cancer, the second leading cause of cancer-related deaths. The most important factor influencing the outcome of patients with an invasive cancer is whether the tumour has spread regionally or systemically. Breast cancer dissemination is a multi-step process, affected by intrinsic, as well as by microenvironmental factors. Metastases start out as single cells that detach from the primary tumour and travel to distal locations. The number of circulating tumour cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer. The biology of these cells is not well comprehended and its understanding is critical for therapeutic improvements. One of the key questions that remain to be fully resolved is what molecular events allow the survival of cancer cells in hostile environment of peripheral blood. Recently, a novel concept arose redefining the molecular basis of survival of breast cancer cells. According to this concept, tumour cells can utilize intracellular (intracrine) receptor-ligand interactions to produce signals necessary for tumour survival under unfavourable conditions. A major scientific objective of the proposed project is to generate, using a transgenic approach, the animal model systems of breast cancer allowing to study the role of intracrine signalling in survival of disseminating breast cancer cells. The work activities detailed in this proposal will have a significant impact on the understanding of the mechanisms of metastasis in early stage breast cancer and thus will facilitate the prevention and/or fight against metastatic breast cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences clinical medicine oncology breast cancer
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-3-IRG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.