Objective
Amyloid fibrils are likely causative or contributing agents in diseases such as Alzheimer’s disease, type 2 diabetes, Parkinson’s disease, and transmissible spongiform encephalopathies. AD represents a major health problem and heavy economic burden in industrialized countries. AD is characterized in pathology by the presence of several kinds of amyloid plaques in the brain patients. The main component of these plaques is the amyloid beta peptide (Ab). Because Ab is suspected to play a crucial role in AD, it represents an obvious therapeutic target. It is therefore, critical to understand the mechanisms by which Ab triggers a neurodegenerative cascade. Current evidence indicates that intraneuronal accumulation of Ab is an early pathological biomarker for the onset of AD. Interestingly, there are evidences showing that exogenous fibrillar Ab can lead to intracellular accumulation of endogenous Ab in cell culture. Recently, exogenous induction of cerebral Ab-amyloidogenesis by injection of amyloid-plaque-containing brain extracts in transgenic mice has been observed. These data are suggestive that exogenous fibrillar Ab are transmissible, by their ability to induce aggregation of endogenous Ab inside the cells. This hypothesizes a molecular mechanism similar to the propagation of the infective amyloid prion proteins. However, there are not yet studies evaluating this hypothesis. In the present application we propose to investigate through which molecular mechanism exogenous Ab aggregates may induces the aggregation of endogenous Ab, and to clarify the relevance of this process for the progression of the disease. For this purpose, we propose to determine whether endocytosed Ab aggregates may propagate their aggregation state to the endogenous Ab in neuronal cells. We propose also to investigate the effect of amyloid structure and metal binding of Ab peptides, the role of RAGE and thioredoxin anti-oxydant system, on Ab internalization and trafficking in neuronal cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine neurology parkinson
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-3-IRG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.