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Targeted delivery of dietary flavanols for optimal human cell function: Effect on cardiovascular health

Objective

Nutrition, i.e. our daily diet, is a major life style factor, greatly impacting on human health and disease. Epidemiological evidence suggests that diets rich in plant-based foods and beverages decrease the risk for cardiovascular morbidity and mortality. Various phytochemical constituents, in particular a class of compounds called flavanols, have been avidly investigated in recent years. Current dietary interventions in humans using flavanol-containing foods have substantiated epidemiological data indicating various potential dietary flavanol-mediated bioactivities, including improved vascular function, decreased blood pressure, attenuated platelet clotting, and improved immune responses. Latest innovations in flavanol analytics, chemistry, food processing technology, and cardiovascular function analysis make the elucidation of underlying mechanisms of flavanol bioactivity not just possible, but also impactful with regard to dietary advice and public health. Thus, a practical application of novel findings emanating from flavanol research in terms of a science/evidence-based development represents a worthwhile endeavour. This entails development of novel food ingredients, and innovative nutrient-delivery matrices. Such novel, nutritionally responsible food formulations hold the potential to open novel avenues in the prevention and amelioration of cardiovascular diseases in Europe. FLAVIOLA aims at: (i) illuminating the cellular and sub-cellular effects of flavanols and their main human metabolites; (ii) investigating key parameters of dietary flavanol absorption, clearance and efficacy towards surrogate markers of cardiovascular function in humans; (iii) developing innovative, functional, and nutritionally responsible food matrices for optimised dietary flavanol delivery; and finally (iv) demonstrating cardiovascular benefits and safety for a newly developed prototype food product.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /engineering and technology/other engineering and technologies/food and beverages
  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases
  • /medical and health sciences/health sciences/nutrition

Call for proposal

FP7-KBBE-2008-2B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Address
Universitaetsstrasse 1
40225 Dusseldorf
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 600 800
Administrative Contact
Doris Neubert (Ms.)

Participants (7)

Mars Belgium
Belgium
EU contribution
€ 311 460
Address
Kleine Kloosterstraat 8
1932 Sint Stevens Woluwe
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ellen Verhoeven (Ms.)
THE UNIVERSITY OF READING
United Kingdom
EU contribution
€ 589 410
Address
Whiteknights Campus Whiteknights House
RG6 6AH Reading
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sarah Page (Ms.)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 450 012
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joseph Ih Janssen (Dr.)
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 299 842
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
Administrative Contact
Charles Mathiaux (Mr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 299 840
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jon Lundberg (Prof.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 300 591
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Vandepitte (Ms.)
SCIPROM SARL
Switzerland
EU contribution
€ 147 240
Address
Rue Du Centre 70
1025 Saint Sulpice
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kirsten Leufgen (Dr.)