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Marine Metagenomics for New Biotechnological Applications

Objective

The Project aims at the mining of individual enzymes and metabolic pathways from extremophilic marine organisms and the metagenomes from microbial communities from peculiar marine environments and consequent funnelling the new enzymatic reactions and processes towards the new biotechnological applications. Project builds up on the scientific and technological excellence of individual academic and industrial partners, and beyond that, on application of the state-of-the-art technologies for archiving, molecular screening for the activities (using a unique Surface Plasmon Resonance screening platform), protein structure elucidation, enzyme engineering and directed evolution and establishing new biotechnological processes (biocatalysis, synthesis of fine chemicals, etc.). Marine sampling hotspots to produce the metagenomic resources for their further exploration will cover the whole diversity of marine microbial life at its limits (hypersaline, low and high temperature, high pressure and low water activity conditions, etc.). Individual enzymes interacting with the substrates will be identified, and in case they are new, hyperexpressed and crystallized and their structures will be elucidated. Consequently, the most promising candidates will be scored against the chiral substrates of relevance for biocatalysis and their ability to perform in water-free systems will be evaluated, the directed evolution will be implemented to improve the performance, and specificity of the enzymes. A comprehensive bioinformatic survey throughout the whole tree of cellular life will reveal and suggest the new candidates homologous to the discovered new proteins, from other organisms to be cloned and assayed. The implementation of the set of new enzymes in the biotechnological processes for fine chemical synthesis and drug discovery will be conducted in a strong alliance with competent industrial partners.

Field of science

  • /engineering and technology/industrial biotechnology/bioprocessing technologies/biocatalysis
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

FP7-KBBE-2008-2B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project
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Coordinator

BANGOR UNIVERSITY
Address
College Road
LL57 2DG Bangor
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 621 144
Administrative Contact
Dyfan Griffith (Mr.)

Participants (10)

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 357 549
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Gaetana Irrera (Ms.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 366 858
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Carlos Manuel Abad Ruiz (Mr.)
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
EU contribution
€ 369 750
Address
Universitaetsstrasse 1
40225 Dusseldorf
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Uwe Droste (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 363 089
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Jean-Michel Portefaix (Mr.)
UNIVERSITE DE BRETAGNE OCCIDENTALE
France
EU contribution
€ 369 828
Address
Rue Des Archives 3
29238 Brest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joel Querellou (Dr.)
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
Canada
Address
Kings College Circle 27
M5S 1A1 Toronto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jennifer Macinnis (Ms.)
Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 277 027
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Heike Wojack (Ms.)
PHARMAMAR, S.A.
Spain
EU contribution
€ 50 000
Address
Avda. De Los Reyes , Poligono Industrial La Mina 1
28770 Colmenar Viejo (Madrid)
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Guillermo Jimenez Díaz (Mr.)
EVOXX TECHNOLOGIES GMBH
Germany
EU contribution
€ 50 000
Address
Alfred Nobel Strasse 10
40789 Monheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thorsten Eggert (Dr.)
INSTITUT DE RECHERCHE PIERRE FABRESAS
France
EU contribution
€ 50 000
Address
Place Abel Gance 45
92100 Boulogne Billancourt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vincent Denoel (Mr.)