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OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life

Objectif

The incidence of childhood obesity has reached ‘epidemic’ proportions globally and there is an urgent need to increase our understanding of the impact of food contaminants on obesity development. The OBELIX project will examine the hypothesis that prenatal exposure to endocrine disrupting compounds (EDCs) in food plays a role in the development of obesity later in life. OBELIX proposes a multidisciplinary approach that combines epidemiology, neonatology, endocrinology, toxicology, analytical chemistry and risk assessment to address the objectives of the project: 1) To assess prenatal exposure in humans to major classes of EDCs in food identified as potential inducers of obesity (i.e. dioxins, non- and dioxin-like polychlorinated biphenyls, brominated flame retardants, phthalates and perfluorinated alkyl acids) using mother-child cohorts from four European regions with different food contaminant exposure patterns; 2) To relate early life exposure to EDCs with clinical markers, novel biomarkers and health effect data related to obesity; 3) To perform hazard characterization of in utero exposure to EDCs for the development of obesity later in life, using dose-response analysis in a rodent model; 4) To determine mechanisms of action of obesogenic EDCs on developmental programming with genomics and epigenetic analysis in in vivo and in vitro models; and, 5) to perform risk assessment of prenatal exposure to obesogenic EDCs in food, by integrating maternal exposure through food, contaminant exposure and health effect data in children, and hazard data. The outcomes of OBELIX are of particular relevance to the Work Programme, as the proposed project will generate new knowledge about prenatal exposure to major classes of EDCs in food that are potential inducers of obesity and related metabolic diseases later in life. It will also contribute new knowledge about effects of early exposure to EDCs on human health, including causality in animal models and possible mechanisms.

Appel à propositions

FP7-KBBE-2008-2B
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Coordinateur

STICHTING VU
Adresse
De Boelelaan 1105
1081 HV Amsterdam
Pays-Bas

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Yvonne Kops (Dr.)
Contribution de l’UE
€ 980 064

Participants (7)

VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.
Belgique
Contribution de l’UE
€ 616 895
Adresse
Boeretang 200
2400 Mol

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Type d’activité
Research Organisations
Contact administratif
Greet Schoeters (Prof.)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Pays-Bas
Contribution de l’UE
€ 808 460
Adresse
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven

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Type d’activité
Research Organisations
Contact administratif
Remco Van Den Dikkenberg (Mr.)
FOLKEHELSEINSTITUTTET
Norvège
Contribution de l’UE
€ 264 138
Adresse
Lovisenberggata 8
0456 Oslo

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Type d’activité
Research Organisations
Contact administratif
Frederik Froen (Mr.)
STICHTING ECOBABY
Pays-Bas
Contribution de l’UE
€ 29 088
Adresse
Hollandstraat 6
3634 AT Loenersloot

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Type d’activité
Research Organisations
Contact administratif
Aart Blom (Dr.)
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
Contribution de l’UE
€ 101 047
Adresse
147 Rue De L'universite
75007 Paris Cedex 07

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Type d’activité
Research Organisations
Contact administratif
Jean-Jacques Petitdidier (Mr.)
SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE
Slovaquie
Contribution de l’UE
€ 200 000
Adresse
Limbova 12
83303 Bratislava

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Milan Cagan (Ms.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Pays-Bas
Adresse
De Boelelaan 1105
1081 HV Amsterdam

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Margot Rijerse (Ms.)