Objective
The aim of the project is the development of robust multiple parallel analytical methodologies allowing for comprehensive and comparative metabolomic descriptions of both control and diabetic rats.
Simultaneously, the development of rapid, user- friendly chemometric "packages" capable of dealing with raw data derived from the above methods and producing meaningful sample classifications and identification of analytes responsible for biochemical perturbations.
The Analytical Challenges are: the management of
- multiple sample preparation and separation/resolution strategies which will include for example CE (with UV-DAD, conductivity or MS detection), HPLC (with coulometric electrochemical array (EC), UV-DAD or MS detection), GC-MS and NMR and
- the data de rived from these techniques in such a way as to produce protocols suitable for comprehensive sample classification and or analyte identification.
Multiple techniques will be combined to yield a multi-dimensional representation for a single sample. Furthermore, chemometric data analysis development of integrated software which can perform rapid analysis of multiple sets of analytical data is a particularly important challenge which will be addressed.
This methodology has multiple applications, but the final objective in this particular project is the knowledge of diabetic rat metabolome in depth, and the effect of antioxidant treatments. It will permit to develop improved strategies for the management of pathologies associated with a major disease such as diabetes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences data science
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences basic medicine pathology
- natural sciences chemical sciences electrochemistry electrophoresis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.