Objective
The aim of the project is the development of robust multiple parallel analytical methodologies allowing for comprehensive and comparative metabolomic descriptions of both control and diabetic rats.
Simultaneously, the development of rapid, user- friendly chemometric "packages" capable of dealing with raw data derived from the above methods and producing meaningful sample classifications and identification of analytes responsible for biochemical perturbations.
The Analytical Challenges are: the management of
- multiple sample preparation and separation/resolution strategies which will include for example CE (with UV-DAD, conductivity or MS detection), HPLC (with coulometric electrochemical array (EC), UV-DAD or MS detection), GC-MS and NMR and
- the data de rived from these techniques in such a way as to produce protocols suitable for comprehensive sample classification and or analyte identification.
Multiple techniques will be combined to yield a multi-dimensional representation for a single sample. Furthermore, chemometric data analysis development of integrated software which can perform rapid analysis of multiple sets of analytical data is a particularly important challenge which will be addressed.
This methodology has multiple applications, but the final objective in this particular project is the knowledge of diabetic rat metabolome in depth, and the effect of antioxidant treatments. It will permit to develop improved strategies for the management of pathologies associated with a major disease such as diabetes.
Fields of science
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencescomputer and information sciencesdata science
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health sciencesbasic medicinepathology
- natural scienceschemical scienceselectrochemistryelectrophoresis
Keywords
Call for proposal
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
EIF - Marie Curie actions-Intra-European FellowshipsCoordinator
LONDON
United Kingdom