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Development of novel nanotechnology based diagnostic systems for Rheumatoid Arthritis and Osteoarthritis

Objective

Based on the clinical unmet needs and recent research in biomarkers on Rheumatoid Arthritis (RA) and Osteoarthritis (OA) the main objective of the project is to develop a nanotechnology based novel diagnostic tool for easy and early detection of biomarkers in inflammatory diseases especially RA and OA by using modified superparamagnetic nanoparticles (SPION) for (A) bioassay (ex-vivo application) and (B) MRI (in-vivo detection). A new technology based on multiple functionalized single nanoparticles specifically entering/attaching to cells, to enzymes in serous fluids or organelles in living cells will be used to detect, separate and identify low abundance biomarkers. Newly identified biomarkers will be used to decorate SPION with binding moieties which are specific to the biomarker(s) and can be used diagnostically such as in contrast agents (MRI). A sensitive micro-immunoassay will be developed for special use of these particles in biochemical tests for arthritis. This project is driven by the high clinical need to identify early arthritis and then segment RA and OA patients into progressors/responders or non-progressors/-responders to various treatment options. Inflammatory disorders like RA inducing the destruction of cartilage in ≈ 1% of the population which is accompanied by significant pain, morbidity and mortality leads to reduced capacity to work. OA, a degenerative arthritis is the leading cause of disability among the elderly population. As there is no cure for RA and finally the replacement of e.g. the knee in OA, early diagnostic tools for the detection of the disease progression and the ability to evaluate the efficacy of therapeutic interventions are necessary u.a. for drug development. Existing diagnostic methods often do not permit an early definite diagnosis, so new nanoparticle based diagnostic techniques targeting to the detection of molecular events (based on MRI) with higher sensitivity/specificity will be developed to satisfy the urgent need.

Field of science

  • /medical and health sciences/health sciences/inflammatory diseases
  • /engineering and technology/nanotechnology
  • /social sciences/sociology/demography/mortality
  • /natural sciences/physical sciences/theoretical physics/particles
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

FP7-NMP-2008-LARGE-2
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

Europäische Akademie zur Erforschung von Folgen wissenschaftlich-technischer Entwicklungen
Address
Wilhelmstraße 56
53474 Bad Neuenahr-ahrweiler
Germany
Activity type
Research Organisations
EU contribution
€ 453 989,50
Administrative Contact
Anja Schlochtermeier (Ms.)

Participants (14)

LUNDS UNIVERSITET
Sweden
EU contribution
€ 853 409,60
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dick Heinegård (Prof.)
TARTU ULIKOOL
Estonia
EU contribution
€ 474 265,60
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Agu Tamm (Prof.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 1 158 714,40
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fraessdorf (Ms.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 1 014 883,60
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Heinrich Hofmann (Prof.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 574 149,20
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Van Oijen (Mr.)
PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG - PRIVATSTIFTUNG
Austria
EU contribution
€ 392 000
Address
Strubergasse 21
5020 Salzburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Felix Eckstein (Prof.)
MERCK SERONO SA
Switzerland
EU contribution
€ 416 017,60
Address
Chemin Des Mines 9
1202 Geneve
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michel Dreano (Dr.)
CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT
Switzerland
EU contribution
€ 574 596,50
Address
Rue Jaquet Droz 1
2000 Neuchatel
Activity type
Research Organisations
Administrative Contact
Helmut Knapp (Dr.)
HOFMANN-AMTENBRINK MARGARETHE
Switzerland
EU contribution
€ 687 904
Address
Ch Jean Pavillard 14
1009 Pully
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Margarethe Hofmann-Amtenbrink (Dr.)
ANAMAR AB
Sweden
EU contribution
€ 479 134,80
Address
Kungsportsavenyn 22
411 36 Goteborg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jan Hed (Dr.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 913 110,40
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jean-Paul Vallee (Prof.)
MERCK CHIMIE SAS
France
EU contribution
€ 95 657
Address
Carnot 201
94120 Fontenay Sous Bois
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Richard Vidal (Dr.)
Arrayon Biotechnology SA
Switzerland
EU contribution
€ 651 691,20
Address
Jaquet-droz 1
2002 Neuchatel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hans Sigrist (Dr.)
UNIVERSITE DE FRIBOURG
Switzerland
EU contribution
€ 177 783,60
Address
Avenue De L Europe 20
1700 Fribourg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Monique Bersier-Lambelet (Ms.)