Objective Based on the clinical unmet needs and recent research in biomarkers on Rheumatoid Arthritis (RA) and Osteoarthritis (OA) the main objective of the project is to develop a nanotechnology based novel diagnostic tool for easy and early detection of biomarkers in inflammatory diseases especially RA and OA by using modified superparamagnetic nanoparticles (SPION) for (A) bioassay (ex-vivo application) and (B) MRI (in-vivo detection). A new technology based on multiple functionalized single nanoparticles specifically entering/attaching to cells, to enzymes in serous fluids or organelles in living cells will be used to detect, separate and identify low abundance biomarkers. Newly identified biomarkers will be used to decorate SPION with binding moieties which are specific to the biomarker(s) and can be used diagnostically such as in contrast agents (MRI). A sensitive micro-immunoassay will be developed for special use of these particles in biochemical tests for arthritis. This project is driven by the high clinical need to identify early arthritis and then segment RA and OA patients into progressors/responders or non-progressors/-responders to various treatment options. Inflammatory disorders like RA inducing the destruction of cartilage in ≈ 1% of the population which is accompanied by significant pain, morbidity and mortality leads to reduced capacity to work. OA, a degenerative arthritis is the leading cause of disability among the elderly population. As there is no cure for RA and finally the replacement of e.g. the knee in OA, early diagnostic tools for the detection of the disease progression and the ability to evaluate the efficacy of therapeutic interventions are necessary u.a. for drug development. Existing diagnostic methods often do not permit an early definite diagnosis, so new nanoparticle based diagnostic techniques targeting to the detection of molecular events (based on MRI) with higher sensitivity/specificity will be developed to satisfy the urgent need. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicinerheumatologymedical and health scienceshealth sciencesinflammatory diseasesengineering and technologynanotechnologynano-materialsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2008-4.0-1 - Development of nanotechnology-based systems for diagnosis and/or therapy for diabetes, muscolo-skeletal or inflammatory diseases (in coordination with Theme HEALTH) Call for proposal FP7-NMP-2008-LARGE-2 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator Europäische Akademie zur Erforschung von Folgen wissenschaftlich-technischer Entwicklungen Address Wilhelmstraße 56 53474 Bad neuenahr-ahrweiler Germany See on map Activity type Research Organisations Administrative Contact Anja Schlochtermeier (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 453 989,50 Participants (14) Sort alphabetically Sort by EU Contribution Expand all Collapse all MAX IV Laboratory, Lund University Sweden EU contribution € 853 409,60 Address Paradisgatan 5c 22100 Lund See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Administrative Contact Dick Heinegård (Prof.) Links Contact the organisation Opens in new window Website Opens in new window TARTU ULIKOOL Estonia EU contribution € 474 265,60 Address Ulikooli 18 51005 Tartu See on map Region Eesti Eesti Lõuna-Eesti Activity type Higher or Secondary Education Establishments Administrative Contact Agu Tamm (Prof.) Links Contact the organisation Opens in new window Website Opens in new window CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 1 158 714,40 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Eveline Fraessdorf (Ms.) Links Contact the organisation Opens in new window Website Opens in new window ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 1 014 883,60 Address Batiment ce 3316 station 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Heinrich Hofmann (Prof.) Links Contact the organisation Opens in new window Website Opens in new window STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 574 149,20 Address Houtlaan 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Wim Van Oijen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG - PRIVATSTIFTUNG Austria EU contribution € 392 000,00 Address Strubergasse 21 5020 Salzburg See on map Region Westösterreich Salzburg Salzburg und Umgebung Activity type Higher or Secondary Education Establishments Administrative Contact Felix Eckstein (Prof.) Links Contact the organisation Opens in new window Website Opens in new window MERCK SERONO SA Switzerland EU contribution € 416 017,60 Address Chemin des mines 9 1202 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michel Dreano (Dr.) Links Contact the organisation Opens in new window Website Opens in new window CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT Switzerland EU contribution € 574 596,50 Address Rue jaquet droz 1 2000 Neuchatel See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Neuchâtel Activity type Research Organisations Administrative Contact Helmut Knapp (Dr.) Links Contact the organisation Opens in new window Website Opens in new window HOFMANN-AMTENBRINK MARGARETHE Switzerland EU contribution € 687 904,00 Address See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Margarethe Hofmann-Amtenbrink (Dr.) Links Contact the organisation Opens in new window ANAMAR AB Sweden EU contribution € 479 134,80 Address Kungsportsavenyn 22 411 36 Goteborg See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jan Hed (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE DE GENEVE Switzerland EU contribution € 913 110,40 Address Rue du general dufour 24 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Administrative Contact Jean-Paul Vallee (Prof.) Links Contact the organisation Opens in new window Website Opens in new window MERCK CHIMIE SAS France EU contribution € 95 657,00 Address Carnot 201 94120 Fontenay sous bois See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Richard Vidal (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Arrayon Biotechnology SA Switzerland EU contribution € 651 691,20 Address Jaquet-droz 1 2002 Neuchatel See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Hans Sigrist (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE DE FRIBOURG Switzerland EU contribution € 177 783,60 Address Avenue de l europe 20 1700 Fribourg See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Fribourg / Freiburg Activity type Higher or Secondary Education Establishments Administrative Contact Monique Bersier-Lambelet (Ms.) Links Contact the organisation Opens in new window Website Opens in new window
