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In Vivo Imaging of Beta cell Receptors by Applied Nano Technology

Objective

Currently, around 30 million people in the enlarged Europe suffer from diabetes, with a prevalence of 7.5% in member states. In recent years the emergence of type 2 diabetes in children and adolescents is a new and serious health challenge to the youth of Europe, their families and society. By 2025, the number of people with diabetes is expected to rise to around 50 million in Europe, thus increasing prevalence to 10.9%. This devastating disease is ranked among the leading causes of fatal cardiovascular diseases, kidney failure, neuropathy, lower limb amputation and blindness. Estimates of annual direct cost of diabetes care in Europe are currently EUR 50 billion. The indirect costs of diabetes i.e. the cost of lost production are as high as direct costs or even higher. Diabetes results from an absolute or relative decline in pancreatic β-cell function and/or mass. Although of ultimate importance for diabetes management and the development of new therapies, hitherto, no clinically established methodology for non-invasive in vivo imaging and quantification of β-cell mass (BCM) exists. VIBRANT proposes superparamagnetic fluorous phase nanocontainers (FPNC), which are functionalized with β-cell specific ligands for in vivo MRI. This combines β-cell specific targeting with the unrivalled MRI sensitivity of supermagnetic particles and the high resolution power of 19F-containing contrast agents, and hence will outperform existing MRI technology. Furthermore, target specific drug-loaded nanocontainers will offer high potential for β-cell directed therapies. VIBRANT will offer theranostic solutions to the utmost urgent problems in the health care management of diabetes, substantially improving the early diagnosis, thus preventing distressful and costly complications, contributing to the development of new therapies for the regeneration of β-cell mass, and thus directly impacting health status and life quality of patients, health care budgets and economies within the EU.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /natural sciences/physical sciences/theoretical physics/particles
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases

Call for proposal

FP7-NMP-2008-LARGE-2
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

Centrum fur Angewandte Nanotechnologie (CAN) GmbH
Address
Grindelallee 117
20146 Hamburg
Germany
Activity type
Research Organisations
EU contribution
€ 1 999 686
Administrative Contact
Theo Schotten (Dr.)

Participants (10)

UNIVERSITAET HAMBURG
Germany
EU contribution
€ 1 067 238
Address
Mittelweg 177
20148 Hamburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Reams-Behboud (Ms.)
NOVO NORDISK A/S

Participation ended

Denmark
EU contribution
€ 61 570,34
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Toby Alexander Brunt (Mr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 1 310 794
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Helena Nässén (Ms.)
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 494 937
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Abdullah Sener (Prof.)
UMEA UNIVERSITET
Sweden
EU contribution
€ 619 574
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tina Ledin (Ms.)
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 491 005
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Stefan Pönisch (Mr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 609 037
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elke Lammertyn (Ms.)
UNIVERSITAET BREMEN
Germany
EU contribution
€ 611 551
Address
Bibliothekstrasse 1
28359 Bremen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sven Petersen (Mr.)
UNIVERSITAT BAYREUTH
Germany
EU contribution
€ 533 888
Address
Universitatsstrasse 30
95447 Bayreuth
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marcus Urban (Mr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 273 719,66
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)