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Regeneration of Cardiac Tissue Assisted by Bioactive Implants

Objective

Heart failure is the end-stage of many cardiovascular diseases, but the leading cause is the presence of a large scar due acute to myocardial infarction. Current therapeutic treatments under development consist in cellular cardiomyoplasty where myocardial cells or stem cells are implanted alone or encapsulated in natural scaffolds (collagens) and grafted onto infarcted ventricles with the hope that cells will contribute to the generation of new myocardial tissue. This approach seems to have a beneficial effect although it is not completely understood and optimized, yet. Thus, the urgent need of better therapeutic platforms is imminent. In view of this, we created a small interdisciplinary consortium (RECATABI) with experts in areas such as material sciences, tissue engineering, stem cell technologies and clinical cardiovascular research. RECATABI will integrate and synergise their capacities in order to obtain a novel clinical platform to regenerate necrotic ischemic tissues after cardiac infarct with a simple one-time patch technology application. The consortium will accomplish this by fabricating nanoscale engineered biomaterials and scaffolds that will match the exact biomechanical and biophysical requirements of the implanted tissue. In addition, the construct may induce rapid vascularization to ensure tissue remodelling and regeneration into a newly functional myocardium. The regenerative capacity of the implants loaded with pre-adapted cells (biomechanically and biophysically trained) will be assessed in small (rodents) and large (sheep) animal models.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/medical biotechnology/tissue engineering
  • /engineering and technology/industrial biotechnology/biomaterials
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases
  • /medical and health sciences/medical biotechnology/medical bioproducts/implants

Call for proposal

FP7-NMP-2008-SMALL-2
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

INSTITUT QUIMIC DE SARRIA
Address
Calle Via Augusta 384-394
08017 Barcelona
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 462 987,40
Administrative Contact
Carlos Semino (Prof.)

Participants (6)

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 397 023,25
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Andrea Zeumann (Ms.)
UNIVERSITAT POLITECNICA DE VALENCIA
Spain
EU contribution
€ 304 185,75
Address
Camino De Vera Sn Edificio 3A
46022 Valencia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jose-Antonio Perez-Garcia (Mr.)
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
EU contribution
€ 410 224,80
Address
Ctra De Canyet S/n
08916 Badalona Barcelona
Activity type
Research Organisations
Administrative Contact
Antonio Martín (Mr.)
ASSOCIATION CARDIO-MONDE
France
EU contribution
€ 370 120,80
Address
Rue De La Tour 116
75116 Paris
Activity type
Research Organisations
Administrative Contact
Juan Carlos Chachques (Dr.)
CREASPINE SAS
France
EU contribution
€ 383 760
Address
Ptib Hopital Xavier Arnozan Avenue Du Haut Leveque
33600 Pessac
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philippe Jenny (Mr.)
FUNDACIO PRIVADA INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU

Participation ended

Spain
Address
Calle Sant Antoni M Claret 167
08025 Barcelona
Activity type
Research Organisations
Administrative Contact
Hilda Herrero (Ms.)