Objective Heart failure is the end-stage of many cardiovascular diseases, but the leading cause is the presence of a large scar due acute to myocardial infarction. Current therapeutic treatments under development consist in cellular cardiomyoplasty where myocardial cells or stem cells are implanted alone or encapsulated in natural scaffolds (collagens) and grafted onto infarcted ventricles with the hope that cells will contribute to the generation of new myocardial tissue. This approach seems to have a beneficial effect although it is not completely understood and optimized, yet. Thus, the urgent need of better therapeutic platforms is imminent. In view of this, we created a small interdisciplinary consortium (RECATABI) with experts in areas such as material sciences, tissue engineering, stem cell technologies and clinical cardiovascular research. RECATABI will integrate and synergise their capacities in order to obtain a novel clinical platform to regenerate necrotic ischemic tissues after cardiac infarct with a simple one-time patch technology application. The consortium will accomplish this by fabricating nanoscale engineered biomaterials and scaffolds that will match the exact biomechanical and biophysical requirements of the implanted tissue. In addition, the construct may induce rapid vascularization to ensure tissue remodelling and regeneration into a newly functional myocardium. The regenerative capacity of the implants loaded with pre-adapted cells (biomechanically and biophysically trained) will be assessed in small (rodents) and large (sheep) animal models. Fields of science medical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinecardiologycardiovascular diseasesengineering and technologyindustrial biotechnologybiomaterialsmedical and health sciencesmedical biotechnologyimplants Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2008-2.3-1 - Advanced implants and bioactive materials for critical organs Call for proposal FP7-NMP-2008-SMALL-2 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator INSTITUT QUIMIC DE SARRIA Address Calle via augusta 384-394 08017 Barcelona Spain See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Administrative Contact Carlos Semino (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 462 987,40 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany EU contribution € 397 023,25 Address Hansastrasse 27c 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Andrea Zeumann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAT POLITECNICA DE VALENCIA Spain EU contribution € 304 185,75 Address Camino de vera sn edificio 3a 46022 Valencia See on map Region Este Comunitat Valenciana Valencia/València Activity type Higher or Secondary Education Establishments Administrative Contact Jose-Antonio Perez-Garcia (Mr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL Spain EU contribution € 410 224,80 Address Ctra de canyet s/n 08916 Badalona barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Antonio Martín (Mr.) Links Contact the organisation Opens in new window ASSOCIATION CARDIO-MONDE France EU contribution € 370 120,80 Address Rue de la tour 116 75116 Paris See on map Activity type Research Organisations Administrative Contact Juan Carlos Chachques (Dr.) Links Contact the organisation Opens in new window CREASPINE SAS France EU contribution € 383 760,00 Address Ptib hopital xavier arnozan avenue du haut leveque 33600 Pessac See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Philippe Jenny (Mr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU FUNDACION Participation ended Spain EU contribution € 0,00 Address C sant quinti 77-79 08041 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Hilda Herrero (Ms.) Links Contact the organisation Opens in new window Website Opens in new window
