Objective Living cells are complex entities with remarkable capacity to sense, integrate and respond to environmental cues. The term directional sensing refers to the ability of a cell to determine the direction and proximity of an extracellular stimulus and to convert this information into biochemical signals. So far, the mechanisms of this extremely complex process are to be elucidated. Undoubtedly, carbohydrates are a class of molecules which together with the proteins span a large spectrum of these mechanisms: from those that are trivial to those that are crucial for the development, growth, function or survival of an organism. Find and Bind aims to explore the potential of this class of molecules to mediate specific recognition events and therefore to provide modulation of biological processes. Approaching and employing the nanoscale mechanisms of the interactions of cells and their physiological milieu Find and Bind will create biological design criteria for the development of new materials and devices constructed from these materials. Taking the cell-matrix adhesion to the third dimension by re-creating both signals and timing of natural occurring events will be applied to develop third generation polysaccharide based constructs. Combining nanostructured scaffolds from naturally derived polymers and the incorporation of biological signals will provide inherent informational guidance in recreating cell-cell interactions and control tissue formation in vitro and in vivo. The long-term innovation potential of the developed constructs as (i) 3D cell instructive materials able to restore and enhance the functions of healthy tissues; (ii) Biosensors and (iii) Surfaces for selective differentiation of stem cells will also be in the targets of this proposal. Fields of science engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensorsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural scienceschemical sciencespolymer sciencesmedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates Keywords Biomolecules Biosensors Stem cells Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2008-1.1-1 - Converging sciences and technologies (nano, bio, info and/or cogni) Call for proposal FP7-NMP-2008-SMALL-2 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSIDADE DO MINHO Address Largo do paco 4704 553 Braga Portugal See on map Region Continente Norte Cávado Activity type Higher or Secondary Education Establishments Administrative Contact Rui L. Reis (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 809 449,00 Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all Stemmatters, Biotecnologia e Medicina Regenerativa Lda Participation ended Portugal EU contribution € 351 440,00 Address Rua arquitecto joão andersen 101 4250-242 Porto See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rui Amandi Sousa (Dr.) Links Contact the organisation Opens in new window Website Opens in new window MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG Germany EU contribution € 445 040,00 Address Universitatsplatz 10 6108 Halle See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Sigrid Köhne (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 410 946,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Janos Vörös (Prof.) Links Contact the organisation Opens in new window Website Opens in new window CHALMERS TEKNISKA HOGSKOLA AB Sweden EU contribution € 400 082,00 Address - 412 96 Goteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Administrative Contact Annika Hofling (Ms.) Links Contact the organisation Opens in new window Website Opens in new window VEREIN ZUR FORDERUNG VON INNOVATIONEN DURCH FORSCHUNG ENTWICKLUNG UNDTECHNOLOGIETRANSFER EV Germany EU contribution € 269 300,00 Address Pruessing strasse 27 b 07745 Jena See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Matthias Schnabelrauch (Dr.) Links Contact the organisation Opens in new window Website Opens in new window FUNDACION TEKNIKER Spain EU contribution € 342 224,00 Address Calle inaki goenaga 5 20600 Eibar guipuzcoa See on map Region Noreste País Vasco Gipuzkoa Activity type Research Organisations Administrative Contact Ana Arizaga (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Q-Sense AB Sweden EU contribution € 242 700,00 Address Hängpilsgatan 7 SE-426 77 Västra frölunda See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Peter Svensson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window HISTOCELL SL Spain EU contribution € 323 647,00 Address Parque tecnologico de bizkaia edificio 801 piso 2 48160 Derio bizkaia See on map Region Noreste País Vasco Bizkaia Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eva González (Ms.) Links Contact the organisation Opens in new window Website Opens in new window STEMMATTERS, BIOTECNOLOGIA E MEDICIINA REGENERATIVA SA Portugal EU contribution € 0,00 Address Parque de ciencia e tecnologia avepark zona industrial da gandra 4805-017 Barco gmr See on map Region Continente Norte Ave Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rui Amandi Sousa (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
