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Find and Bind: Mastering sweet cell-instructive biosystems by copycat nano-interaction of cells with natural surfaces for biotechnological applications

Objective

Living cells are complex entities with remarkable capacity to sense, integrate and respond to environmental cues. The term directional sensing refers to the ability of a cell to determine the direction and proximity of an extracellular stimulus and to convert this information into biochemical signals. So far, the mechanisms of this extremely complex process are to be elucidated. Undoubtedly, carbohydrates are a class of molecules which together with the proteins span a large spectrum of these mechanisms: from those that are trivial to those that are crucial for the development, growth, function or survival of an organism. Find and Bind aims to explore the potential of this class of molecules to mediate specific recognition events and therefore to provide modulation of biological processes. Approaching and employing the nanoscale mechanisms of the interactions of cells and their physiological milieu Find and Bind will create biological design criteria for the development of new materials and devices constructed from these materials. Taking the cell-matrix adhesion to the third dimension by re-creating both signals and timing of natural occurring events will be applied to develop third generation polysaccharide based constructs. Combining nanostructured scaffolds from naturally derived polymers and the incorporation of biological signals will provide inherent informational guidance in recreating cell-cell interactions and control tissue formation in vitro and in vivo. The long-term innovation potential of the developed constructs as (i) 3D cell instructive materials able to restore and enhance the functions of healthy tissues; (ii) Biosensors and (iii) Surfaces for selective differentiation of stem cells will also be in the targets of this proposal.

Call for proposal

FP7-NMP-2008-SMALL-2
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Coordinator

UNIVERSIDADE DO MINHO
Address
Largo Do Paco
4704 553 Braga
Portugal

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rui L. Reis (Prof.)
EU contribution
€ 809 449

Participants (9)

Stemmatters, Biotecnologia e Medicina Regenerativa Lda

Participation ended

Portugal
EU contribution
€ 351 440
Address
Rua Arquitecto João Andersen 101
4250-242 Porto

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rui Amandi Sousa (Dr.)
MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG
Germany
EU contribution
€ 445 040
Address
Universitatsplatz 10
6108 Halle

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sigrid Köhne (Dr.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 410 946
Address
Raemistrasse 101
8092 Zuerich

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Janos Vörös (Prof.)
CHALMERS TEKNISKA HOGSKOLA AB
Sweden
EU contribution
€ 400 082
Address
-
412 96 Goteborg

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Annika Hofling (Ms.)
VEREIN ZUR FORDERUNG VON INNOVATIONEN DURCH FORSCHUNG ENTWICKLUNG UNDTECHNOLOGIETRANSFER EV
Germany
EU contribution
€ 269 300
Address
Pruessing Strasse 27 B
07745 Jena

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Activity type
Research Organisations
Administrative Contact
Matthias Schnabelrauch (Dr.)
FUNDACION TEKNIKER
Spain
EU contribution
€ 342 224
Address
Calle Inaki Goenaga 5
20600 Eibar Guipuzcoa

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Activity type
Research Organisations
Administrative Contact
Ana Arizaga (Ms.)
Q-Sense AB
Sweden
EU contribution
€ 242 700
Address
Hängpilsgatan 7
SE-426 77 Västra Frölunda

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Svensson (Mr.)
HISTOCELL SL
Spain
EU contribution
€ 323 647
Address
Parque Tecnologico De Bizkaia Edificio 801 Piso 2
48160 Derio Bizkaia

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva González (Ms.)
STEMMATTERS, BIOTECNOLOGIA E MEDICIINA REGENERATIVA SA
Portugal
Address
Parque De Ciencia E Tecnologia Avepark Zona Industrial Da Gandra
4805-017 Barco Gmr

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rui Amandi Sousa (Dr.)