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Nanopatterned scaffolds for active myocardial implants

Objective

Cell therapy and tissue engineering are emerging as novel therapeutic paradigms for myocardial repair. The rationale behind the cell replacement approach is based on the assumption that an increase in the number of functional cardiomyocytes within the diseased area may improve the mechanical properties of this compromised region. A common strategy attempts to initially combine, ex-vivo, cells with polymeric scaffolds to generate a construct, followed by in-vivo engraftment onto the heart muscle. Despite first encouraging results, the clinical utility of these approaches is hampered by the paucity of cell sources for human cardiomyocytes and by the limited direct functional integration of grafted cells and high degree of donor cell death following cell grafting in host myocardial tissue. NanoCARD will create a conceptually new type of biomimetic nanoscopically designed scaffold able to generate cardiac tissue replacement for the myocardium. Within our project we will design novel cellular environments with broad but precisely-controlled diversity in chemical composition, physical properties, and geometrical spacing of individual peptides on the nanometre scale. The capability of these environments to regulate cell response will be explored by high throughput approaches using a new chip technology developed within the project. An additional unique concept for controlling the function of cardiac cells is given by applying periodic mechanical strain in the range of heart frequency during the tissue engineering process. The knowledge gained within NanoCARD will be translated into the design and production of a novel biocompatible nanostructured device (therapeutic surface) with a desired bioactivity inducing specific behaviour of endothelial cells and cardiomyocytes to revolutionise treatment of myocardial defects. The inclusion of relevant companies in the consortium assures the identification of opportunities for the intended product developments.

Call for proposal

FP7-NMP-2008-SMALL-2
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Address
Hofgartenstrasse 8
80539 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 794 600
Administrative Contact
Joachim Spatz (Prof.)

Participants (12)

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 278 100
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Viola Vogel (Prof.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 549 500
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Harm - Anton Klok (Prof.)
CHALMERS TEKNISKA HOEGSKOLA AB
Sweden
EU contribution
€ 187 500
Address
-
41296 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Annika Hofling (Ms.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 432 500
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV
Israel
EU contribution
€ 339 000
Address
Weizmann Street 6
64239 Tel Aviv
Activity type
Research Organisations
Administrative Contact
Michal Roll (Dr.)
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
EU contribution
€ 361 500
Address
Senate Building Technion City
32000 Haifa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Shulamit Levenberg (Dr.)
SCUOLA NORMALE SUPERIORE
Italy
EU contribution
€ 256 500
Address
Piazza Dei Cavalieri 7
56126 Pisa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniele Altamore (Dr.)
QIAGEN GMBH
Germany
Address
Qiagen Strasse 1
40724 Hilden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ann Vinckier (Ms.)
CELLMADE SAS
France
EU contribution
€ 133 260
Address
Rue De La Cure 16
63720 Chappes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ronald Bronsaer (Mr.)
Idea Bio-Medical Ltd.
Israel
EU contribution
€ 296 000
Address
Prof. Bergman St. 2
76705 Rehovot
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Yuval Keren (Mr.)
CellTech Services Götz GmbH

Participation ended

Germany
Address
Uhlandstr. 16
63500 Seligenstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alexander Götz (Dr.)
EVERCYTE GMBH
Austria
EU contribution
€ 178 140
Address
Leberstrasse 20/8
1110 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Otto Kanzler (Mr.)