Objective Cell therapy and tissue engineering are emerging as novel therapeutic paradigms for myocardial repair. The rationale behind the cell replacement approach is based on the assumption that an increase in the number of functional cardiomyocytes within the diseased area may improve the mechanical properties of this compromised region. A common strategy attempts to initially combine, ex-vivo, cells with polymeric scaffolds to generate a construct, followed by in-vivo engraftment onto the heart muscle. Despite first encouraging results, the clinical utility of these approaches is hampered by the paucity of cell sources for human cardiomyocytes and by the limited direct functional integration of grafted cells and high degree of donor cell death following cell grafting in host myocardial tissue. NanoCARD will create a conceptually new type of biomimetic nanoscopically designed scaffold able to generate cardiac tissue replacement for the myocardium. Within our project we will design novel cellular environments with broad but precisely-controlled diversity in chemical composition, physical properties, and geometrical spacing of individual peptides on the nanometre scale. The capability of these environments to regulate cell response will be explored by high throughput approaches using a new chip technology developed within the project. An additional unique concept for controlling the function of cardiac cells is given by applying periodic mechanical strain in the range of heart frequency during the tissue engineering process. The knowledge gained within NanoCARD will be translated into the design and production of a novel biocompatible nanostructured device (therapeutic surface) with a desired bioactivity inducing specific behaviour of endothelial cells and cardiomyocytes to revolutionise treatment of myocardial defects. The inclusion of relevant companies in the consortium assures the identification of opportunities for the intended product developments. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologyimplantsmedical and health sciencesmedical biotechnologycells technologies Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2008-2.3-1 - Advanced implants and bioactive materials for critical organs Call for proposal FP7-NMP-2008-SMALL-2 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Address Hofgartenstrasse 8 80539 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Administrative Contact Joachim Spatz (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 794 600,00 Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 278 100,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Viola Vogel (Prof.) Links Contact the organisation Opens in new window Website Opens in new window ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 549 500,00 Address Batiment ce 3316 station 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Harm - Anton Klok (Prof.) Links Contact the organisation Opens in new window Website Opens in new window CHALMERS TEKNISKA HOGSKOLA AB Sweden EU contribution € 187 500,00 Address - 412 96 Goteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Administrative Contact Annika Hofling (Ms.) Links Contact the organisation Opens in new window Website Opens in new window WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution € 432 500,00 Address Herzl street 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Administrative Contact Talia Tzahor (Ms.) Links Contact the organisation Opens in new window Website Opens in new window THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV Israel EU contribution € 339 000,00 Address Weizmann street 6 64239 Tel aviv See on map Administrative Contact Michal Roll (Dr.) Links Contact the organisation Opens in new window Website Opens in new window TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Israel EU contribution € 361 500,00 Address Senate building technion city 32000 Haifa See on map Activity type Higher or Secondary Education Establishments Administrative Contact Shulamit Levenberg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window SCUOLA NORMALE SUPERIORE Italy EU contribution € 256 500,00 Address Piazza dei cavalieri 7 56126 Pisa See on map Region Centro (IT) Toscana Pisa Activity type Higher or Secondary Education Establishments Administrative Contact Daniele Altamore (Dr.) Links Contact the organisation Opens in new window Website Opens in new window QIAGEN GMBH Germany EU contribution € 0,00 Address Qiagen strasse 1 40724 Hilden See on map Region Nordrhein-Westfalen Düsseldorf Mettmann Administrative Contact Ann Vinckier (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CELLMADE SAS France EU contribution € 133 260,00 Address Rue de la cure 16 63720 Chappes See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ronald Bronsaer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Idea Bio-Medical Ltd. Israel EU contribution € 296 000,00 Address Prof. bergman st. 2 76705 Rehovot See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Yuval Keren (Mr.) Links Contact the organisation Opens in new window CellTech Services Götz GmbH Participation ended Germany EU contribution € 0,00 Address Uhlandstr. 16 63500 Seligenstadt See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Alexander Götz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EVERCYTE GMBH Austria EU contribution € 178 140,00 Address Leberstrasse 20/8 1110 Wien See on map Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Otto Kanzler (Mr.) Links Contact the organisation Opens in new window Website Opens in new window
