Objective The aim of the proposal is to fortify and intensify the scientific exchange and connectivity between four groups - two in Europe (European consortium) and two in the USA - that have a proven record in collaboration over the past years. The common theme, on which the scientific collaborations are based, is “Proteomics & Epi-Genetics of Anion transport” (PEG-Anion). Epi-Genetics refers to how inherited genetic information, and genetic information not encoded in the DNA sequence translates into variations in overall function of the gene products. Extending the existing collaboration between the PEG-Anion partner-laboratories into a PEG-ANION-NETWORK (PEG-ANION-NET) would add significant momentum to the knowledge-transfer between the four groups. The groups have individual funding for the respective PEG-Anion projects, and the exchange scheme (IRSES) will help to sustain the research activity between the four groups by covering the mobility expenses induced by the planned PEG-ANION-NET activity. The project: The sequencing of the human genome was a milestone in science and marked the beginning of the post-genomic era. The knowledge of the genomic make up, however, does not by itself give much insight into the function of single genes, nor does it give conclusive answers on the effect of single genes or gene products in regulatory circuits established in living cells. The challenge now and in the immediate future is to combine the genomic- and epigenetic-information with functional-information of the gene products in their native environment. The research in the PEG-Anion partner-laboratories is focused on the proteomics, genomics and epigenetics of two anion ‘transporters’ and how these factors translates into the respective gene product function. Genetic make-up, proteomic interaction and epigenetic regulation of gene expression are important for normal cellular physiology and play key roles in both disease progression and responses to therapeutic intervention. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesbasic medicinephysiologynatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesgeneticsepigenetics Keywords Cell biology Epigenetics Genetics Medicine Oncology Pendred Physiology Proteomics Rare diseases Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-IRSES-2008 - Marie Curie Action "International Research Staff Exchange Scheme" Call for proposal FP7-PEOPLE-IRSES-2008 See other projects for this call Funding Scheme MC-IRSES - International research staff exchange scheme (IRSES) Coordinator PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG - PRIVATSTIFTUNG EU contribution € 381 600,00 Address STRUBERGASSE 21 5020 Salzburg Austria See on map Region Westösterreich Salzburg Salzburg und Umgebung Activity type Higher or Secondary Education Establishments Administrative Contact Markus Paulmichl (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data