Objective
Oxidative stress results from an imbalance between the generation of reactive oxygen species and the antioxidant defense mechanisms. In recent years, oxidative stress has been implicated in a variety of detrimental health conditions including cardiovascular diseases, neurodegenerative disorders, and other types of age-related diseases. Evidence shows that the formation of superoxide radicals is a common denominator associated with all these conditions. Considering that cardiovascular diseases are the number one cause of death globally and neurodegenerative diseases are becoming a major health burden due to the aging of the global population, it is not surprising that a great deal of interest has been shown to develop new therapeutic approaches for scavenging these dangerous radicals. Superoxide dismutases (SODs) are endogenous metalloenzymes that catalyze the dismutation of these radicals into the less toxic dioxygen and hydrogen peroxide. Thus, they play a key role in cellular protection against oxidative stress conditions. The present proposal will focus on the design, synthesis and characterization of Mn/Fe SOD peptide mimics. The working hypothesis is that by designing peptides that contain the same metal binding sites as those present in the native SODs there is potential for developing novel structural and functional SOD mimics. To this aim, different native-like protein/peptide scaffolds will be prepared. Mn and Fe binding affinities, redox potentials and SOD activity will be determined for the different constructs with the objective of obtaining crucial structure-activity-redox relationships. The completion of this research will increase our understanding of the structural basis needed for the dismutation of superoxide radicals. As this understanding evolves and is further refined, it should allow us and other research groups to make inroads in designing more effective SOD mimics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine cardiology cardiovascular diseases
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IRG-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2784-505 OEIRAS
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.