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Content archived on 2024-05-30

Identification of the protein interactome of the A2A-adenosine receptor

Final Report Summary - ADENOSINE-RECEPTOR (Identification of the protein interactome of the A2A-adenosine receptor)

Proteins can be viewed like social actors, they form many different complexes with each other. A receptor that resides on the cell surface membrane of a given cell is actually synthesized at a very different site, namley in the endoplasmic reticulum. From this site of its birth, it has to travel to the surface. Because G protein-coupled receptors are membrane proteins, they cannot simply travel through the aqueous milieu of the cytosol. They must stay embedded in a membrane. They are The project aimed at understanding which