Objective
Several lines of evidence suggest an interplay between apical-basal polarity (ABP) and Notch (N) signaling in epithelia. Available data indicate that modulation of N signaling can occur through both direct regulation of the activity and mislocalization of either the receptor or the ligand. The purpose of this project is to understand how N activity can be modulated by differential regulation of apical-basal components or, in general, subcellular domains. A genetic screen among genes involved in ABP, ranging from regulators of vesicular trafficking or protein sorting to polarity regulators themselves, will help us identify the components underlying this modulation. Further genetic analysis together with molecular biology and biochemistry studies will help understand the molecular mechanisms of N activity modulation by ABP. Both ABP regulators and N pathway members have been shown to be involved in crucial events during development and tissue homeostasis, such as control of epithelial integrity and cell division, that, when distorted, can lead to tissue overgrowth and eventually cancer. Nevertheless, the molecular mechanisms underlying these processes are very poorly understood. This project will help shed light on these mechanisms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology homeostasis
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IRG-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.