Objective
My project will investigate the interactions between the mitochondrial and nuclear genomes. Proteins encoded by both genomes are required for cell respiration, the main source of energy production in eukaryotes. Selection is strong for optimal function of cell respiration, leading to coadaptation of mitochondrial and nuclear genes (“cytonuclear coevolution”). Experiments have show that the breakup of such coadapted gene complexes can lead to hybrid breakdown, which may reduce gene flow between populations and generate reproductive isolation. Hence, cytonuclear coevolution can be important in generating intraspecific genetic diversity. I will use a threefold approach to evaluate the importance of cytonuclear coevolution in natural populations, using a hybrid zone in the black-tailed brush lizard as a model system. Firstly, I will investigate cytonuclear coadaptation at the nucleotide level by studying sequence variation in interacting genes within and between hybridizing populations. Secondly, I will study the fitness consequences of cytonuclear coevolution by comparing enzyme activity of coadapted versus maladaptive gene products. Finally, I will evaluate the potential for cytonuclear coevolution to generate reproductive isolation by using single nucleotide polymorphisms (SNPs) and nuclear intron sequences to evaluate nuclear genomic divergence. This research will provide a fundamental contribution to understanding reproductive isolation and genetic diversity in natural populations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences genetics nucleotides
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IRG-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
751 05 Uppsala
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.