Objective
The basal ganglia are a group of sub-cortical brain nuclei involved in motor related tasks such as motor planning, selection, and execution, as well as in a variety of cognitive functions such as attention and memory. Malfunctions of basal ganglia are related to diseases and disorders such as Parkinson's disease, Huntington disease, Tourette's syndrome, and others.
The input layer of the basal ganglia is the striatum, consisting mainly of GABAergic spiny neurons, which project to the other basal ganglia nuclei via direct and indirect pathways. These pathways are believed to be crucial for selection and execution of motor tasks. The striatum receives most of its excitatory input from various cortical areas, via the corticostriatal pathway. Despite the vast anatomical knowledge of the striatum and the corticostriatal pathway, little is known about the intrastriatal and corticostriatal microcircuit properties. In this study I will use multi-neuron patch-clamp recordings combined with retrograde fluorescent labelling, morphological 3D reconstruction and single-cell RT-PCR, to obtain a detailed description of the electrophysiological, morphological, and synaptic properties of the intrastriatal and corticostriatal microcircuitry.
The aim of this study is to obtain fundamentally new insights about the functional organization of the striatum and its cortical afferents, and the way they participate in motor control and selection of behaviour. The study will therefore also have direct bearing on the understanding of basal ganglia-related disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology cognitive neuroscience
- medical and health sciences basic medicine neurology dementia
- medical and health sciences basic medicine neurology parkinson
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.