Objective
Cell migration is needed during development of multi-cellular organisms, but it is also involved in pathological conditions, like invasive migration of tumour cells leading to metastases. Conversion of stationary epithelial cells to invasive migratory cells involves changes in transcription, cytoskeletal organization as well as cell signalling pathways.
That specific transcription factors are required for cells to become migratory in each system where it has been investigated, emphasizes the importance of transcriptional changes. The migration of border cells during Drosophila oogenesis provides a powerful genetically tractable model to study developmentally regulated invasive cell migration in vivo. The aim of the study is to find novel genes regulating cell migration in order to better understand how cells become migratory in vivo.
The proposed project is based on gene expression profiling (microarray) analysis of migrating border cells recently performed in the Rorth lab. The objective of the study is to identify putative regulators of cell migration by targeted gene silencing of candidate genes obtained from the micro-array analysis. The effect of gene silencing will be studied in three different migration models in Drosophila, namely border cells, hemocytes, and recently developed Drosophila model for tumour metastasis. In addition to novel insights into cell migration during development, the results obtained in this study have potential to further our understanding of genes and mechanisms involved in cancer metastasis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences genetics RNA transcriptomes
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.