Objective
The bacterium Escherichia coli is one of the best-studied free-living organisms. However, extensive genotypic differences exist between E. coli species, likely due to differences in lifestyle, some strains being harmless commensals whereas others are serious human pathogens.
Completed genome sequences of different E. coli strains have revealed that a high percentage of these genes still have unassigned or poorly characterized function. Current hypotheses consider that this could be partly due to the fact that most of the studies with E. coli have been performed under physiological conditions where these genes are not functional. The intracellular biofilm communities formed by uropathogenic E. coli strains allow bacteria to subvert host defences and constitute a persistent reservoir of infection.
The aim of this project is to identify factors involved in biofilm formation of the uropathogenic E. coli strain and quot;CFT073 that are usually cryptic under laboratory conditions, using two alternative strategies:
- a random conditional over-expression combined with a biofilm positive selection and
- a reverse genetic analysis of uncharacterized potential functional homologues of known adhesins.
These approaches may reveal new biofilm functions leading to a better understanding of the bacterial biology within biofilms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine urology
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences microbiology bacteriology bacteriomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.