Objective
Recently, the design of new brain repair strategies based on stem cell transplantation has received a tremendous amount of attention.
This has been due to the increased incidence of neurodegenerative diseases and the absence of effective chemically based therapies. In this context the potential use of stem cells for transplantation appears as a promising alternative to restore lost cells (i.e. neurons or oligodendrocytes) in the central nervous system (CNS).
In this context, adult neural progenitors derived from olfactory neuroepithelium could constitute an excellent candidate.
Olfactory neuroepithelium is a unique source of adult human progenitors, which can be obtained from an individual without invasive surgery. These cells have the capacity to continually replace damaged neurons and glia throughout life; they can be amplified in vitro and create neurospheres and they can adopt a neuronal or glial fate depending on environmental factors. They survive, integrate and are functional when transplanted into a rat model of injured spinal cord.
We propose to further study olfactory neuroepithelium cells and to develop in vitro amplification and differentiation procedures to obtain a pure population of committed progenitors for transplantation into damaged CNS or for use in drug research, pharmacological evaluation and gene manipulation.
As a first step to use adult olfactory progenitors to facilitate CNS repair, we propose to test the capacity of these cells to differentiate into dopaminergic phenotype and investigate their restorative capacity when grafted into a denervated striatum.
Analogously, the potential of adult olfactory progenitors to differentiate into oligodendrocytic phenotype and to restore oligodendrocytes will be evaluated in hypomyelinated corpus callosum of mice affected by genetically determined myelinopathy (shiverer mice).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine surgery
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine transplantation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-ERG-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00179 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.