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Analysis of the molecular mechanisms of antigen presentation to B cells by macrophages in lymphoid organs

Objective

B cell activation is triggered by antigen recognition through the B cell receptor (BCR). It has been evidently shown that the antigen encountered in vivo by B cells is mainly membrane-bound. However, the molecular events involved in the process of recognition are not yet undertaken. Dr. Batista’s lab has very recently shown that macrophages collect and concentrate particulate antigen at the lymph node, where it is then encountered and acquired by follicular B cells. So, the principal aim of this proposal is to investigate and define the molecular mechanisms that govern this novel way of antigen presentation to B cells, mediated by macrophages at the spleen and lymph node. To carry this out, we propose to investigate the macrophage membrane proteins involved in the antigen presentation, such as mannose receptor or SIGNR1 (murine homologue to DC-SIGN) and complement. These studies are likely to shed light into how B cell responses are initiated which direct implications in vaccine design and autoimmunity.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins

Call for proposal

FP7-PEOPLE-IEF-2008
See other projects for this call

Funding Scheme

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

CANCER RESEARCH UK LBG
Address
St John Street 407 Angel Building
EC1V 4AD London
United Kingdom
Activity type
Research Organisations
EU contribution
€ 171 867,63
Administrative Contact
Louisa Jacobs (Ms.)