Skip to main content
European Commission logo
English English
CORDIS - EU research results
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary
Content archived on 2024-05-30

Analysis of the molecular mechanisms of antigen presentation to B cells by macrophages in lymphoid organs

Objective

B cell activation is triggered by antigen recognition through the B cell receptor (BCR). It has been evidently shown that the antigen encountered in vivo by B cells is mainly membrane-bound. However, the molecular events involved in the process of recognition are not yet undertaken. Dr. Batista’s lab has very recently shown that macrophages collect and concentrate particulate antigen at the lymph node, where it is then encountered and acquired by follicular B cells. So, the principal aim of this proposal is to investigate and define the molecular mechanisms that govern this novel way of antigen presentation to B cells, mediated by macrophages at the spleen and lymph node. To carry this out, we propose to investigate the macrophage membrane proteins involved in the antigen presentation, such as mannose receptor or SIGNR1 (murine homologue to DC-SIGN) and complement. These studies are likely to shed light into how B cell responses are initiated which direct implications in vaccine design and autoimmunity.

Call for proposal

FP7-PEOPLE-IEF-2008
See other projects for this call

Coordinator

CANCER RESEARCH UK LBG
EU contribution
€ 171 867,63
Address
2 Redman Place
E20 1JQ LONDON
United Kingdom

See on map

Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Administrative Contact
Louisa Jacobs (Ms.)
Links
Total cost
No data