Objective
Phosphorylation of proteins and metabolites is an essential mechanism for signal transduction and propagation in the cell and thus of utmost importance for cellular function. In spite of this, there is a lack of synthetic chemical receptors for the detection and separation of phosphoesters that combine selectivity and sensitivity. In this project we aim to develop novel chemical receptors for the efficient recognition of phosphorylated molecules of biological interest. The design of such receptors will be based on metallo-receptors that combine strong binding (through metal-phosphate interactions) with high selectivity (provided by hydrogen-bonding groups and other reversible interactions). In order to assemble the different components of the receptors, we propose to use dynamic combinatorial chemistry (DCC) using the phosphorylated species of interest as templates to “amplify” the best receptors from the virtual dynamic combinatorial library. Once the best receptors are identified using the above methodology and their selectivity and sensitivity are optimised, they will be used for the development of chemical sensors to detect specific phosphorylated species. This will be carried out by incorporating optical labels that change their properties upon binding between receptor and phosphorylated guest. Particular emphasis will be given to the detection of phosphorylated phosphoinositides since they play important roles in cell signalling and regulation and their levels can be correlated to the molecular basis of certain diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IIF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.