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Molecular Mechanisms of Cell Entry of Enveloped Viruses

Objective

Virus infections are a major cause of diseases and death among men and animals. The recent outbreak of SARS and the danger that an avian influenza virus may become pandemic, have clearly shown that members of any virus family can potentially turn into a pathogen. To combat virus infection and propagation, systematic and comprehensive studies both on viral components mediating virus-cell interactions, and on the cell biology behind virus entry are necessary. Our network, teaming academic and industrial groups, is aimed at undertaking an interdisciplinary effort to reveal the diversity of pathways and associated molecular mechanisms of cell entry of enveloped viruses. Research by experimental and theoretical approaches will be directed towards the identification of cellular receptors and of viral fusion proteins responsible for interaction with host cells. Among topics are folding, three-dimensional structure and conformational changes of viral fusion proteins as well as virus triggered signalling cascades in cells. Biophysical approaches will unravel the relationship between energetics of conformational changes of viral proteins and membrane bending and fusion. Together with industrial partners the project will identify potential targets for designed drug development, and will develop virus protein coated nanoparticles as new biotechnological and medical tools. The groups have complementary expertise at the highest standard in all required techniques of virology, molecular and cellular biology, biochemistry, proteomics, structural biology, theoretical and experimental biophysics. A challenging research and training environment in an international setting will provide young scientists with a network wide research-oriented training devoted to the specific aspects of virus entry and to structuring of industry projects and commercial exploitation of results, and a local training in soft skills and basic complementary education adapted to the personal needs.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /natural sciences/biological sciences/microbiology/virology
  • /medical and health sciences/health sciences/infectious disease/RNA virus/coronavirus
  • /medical and health sciences/health sciences/epidemiology/pandemics
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/molecular biology/structural biology

Call for proposal

FP7-PEOPLE-ITN-2008
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

HUMBOLDT-UNIVERSITAET ZU BERLIN
Address
Unter Den Linden 6
10117 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 557 486
Administrative Contact
Ulrich Winderl (Mr.)

Participants (8)

UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 809 040
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ricardo Fernandez (Mr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 240 341
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingwar Lennerfors (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 401 904
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Michèle Saumon (Dr.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 454 486
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ari Helenius (Prof.)
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 424 700
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lea Pais (Ms.)
INSTITUT PASTEUR
France
EU contribution
€ 364 117
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Felix Rey (Prof.)
FREIE UNIVERSITAET BERLIN
Germany
EU contribution
€ 393 807
Address
Kaiserswerther Strasse 16-18
14195 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Veit (Dr.)
Capsulution Pharma AG
Germany
EU contribution
€ 199 102
Address
Volmerstrasse 7B
12489 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alexander Herrmann (Mr.)