Objective
The incidence and prevalence of dementia is rising as the world-wide population ages. Determining biomarkers for the early detection of underlying biology that will predict dementia progression reliably or, the monitoring of biological processes once present to track progression and treatment is necessary. Furthermore, these biomarkers will aid in the differentiation of dementia from normal ageing and between its subtypes, and in the development of sensitive and specific diagnostic and treatment methods. The current study will be the first to assess a new protein-aggregating biomarker of dementia, TAR-DNA-binding-protein-43 (TDP-43), in a population-based sample. TDP-43 was implicated in the biology of dementia in 2006 however its relevance to the population is unknown. This study will assess the significance of TDP-43 in relation to dementia in a population sample of older people who have undergone brain donation. The sample (n=350) is from the European Clinicopathological Studies in Europe (EClipSE). Each participant has been tracked longitudinally for up to twenty years (dependent on date of death), with clinical (e.g. dementia and other diagnoses such as diabetes, cognition and psychological symptomatology) data available. The three study objectives are: • The determination of the prevalence of pathological TDP-43 expression in a population-based sample of older people as a whole and relative to dementia status. • The determination of the relationships between pathological TDP-43 expression and other neuropathological markers of dementia as well as longitudinal cognition and psychological symptomatology. • The development of clinical criteria which are sensitive and specific to the presence of pathological TDP-43 expression during life. These investigations will have significant implications for the diagnosis, management and treatment of dementia syndromes, with the aim of decreasing the social and economic costs of dementia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine neurology dementia
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IIF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1TN Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.