Objective
Vertebrate brain development and function require the life-long regulation of neural stem cell maintenance and neuronal production. Recent evidence, in part obtained in the host laboratory, suggest that the microRNA miR-9 might be an important regulator of neurogenesis, by driving neural progenitors towards differentiation. Notably, injection of a miR-9 morpholino antisense oligonucleotide into zebrafish embryos decreases neuronal differentiation in the embryonic hindbrain. The spatio-temporal expression pattern of miR-9 is suggestive of a neuronal subtype-specific action. The researcher will thus characterize more precisely the neuronal deficit of miR-9 morphant embryos, using markers of different neuronal populations. To understand the mechanisms underlying miR-9 function, the interaction between miR-9 and selected in silico predicted targets will be tested, and an innovative microarray-based biochemical approach for identifying targets in vivo will be developped. The NEuromiR project also includes epistasis experiments to connect miR-9 action with that of other neurogenesis regulators (Rest, Her) expressed in progenitors. Finally, in a longer term and to extend the findings to later developmental stages and adulthood, zebrafish transgenic lines that enable to conditionally enhance or deplete miR-9 function will be engineered. Together, this project will shed light onto the fine-tuning of neurogenesis control by microRNAs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
85764 Neuherberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.