Objective
Iron-sulphur (Fe-S) proteins are crucial to life-sustaining processes such as respiration, photosynthesis and nitrogen fixation. These metalloproteins contain ancient but versatile co-factors, called Fe-S clusters, consisting of iron and acid-labile sulphide. In plant cells, evolutionary conserved Fe-S cluster assembly pathways have been localized to the mitochondria, plastids and the cytosol. Whereas the last decade was dedicated to the characterization of individual components, we still do not know how the pathways interact in plants, although there is evidence for such interaction. In particular, deletion of the mitochondrial ABC transporter AtATM3 is known to impair plastid functions. In this proposal, I will address the relationship between the compartmentalized Fe-S cluster assembly machineries in plants. I will use both reverse and forward genetic approaches in the model plant Arabidopsis thaliana to obtain a map of the interactions between Fe-S assembly pathways. First, using selected mutants, I will assess whether impairment of one specific pathway affects the assembly of Fe-S proteins in other cell compartments. Second, to investigate how AtATM3 is involved in chloroplast functions and get clues about its substrate, I will search for mutations that suppress the chlorotic phenotype of atm3 mutant. Possible interactions with Fe homeostasis will also be investigated. This fellowship will introduce me to a novel model organism and new techniques, within a very successful Anglo-Saxon education model (Cambridge) from which I hope to take elements for my future research/teaching career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- medical and health sciences basic medicine physiology homeostasis
- natural sciences biological sciences botany
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.