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Content archived on 2024-06-18

Synthesis of Targeted Organometallic Anticancer Drugs and their mode of Action

Final Report Summary - STOADA (Synthesis of targeted organometallic anticancer drugs and their mode of action)

New hybrid complexes composed of ruthenium(II)-arene units with curcumin and pta have beenprepared and evaluated for their medicinal (anticancer) properties. These compounds were characterised by NMR spetroscopy, elemental analyses and mass spectrometry. Biological studies of these compounds on the A2780 and A2780cisR cancer cell lines reveal moderate activity. Screening for enzymatic inhibition of the physiologically dominant carbonic anhydrase isozymes show that the compounds are modest inhibitors.

The results obtained in this project provide an opening towards the estimation of possibility of using ruthenium(II)-curcuminate complexes as possible anticancer drugs. As the project has been ended abruptly due to the return of the fellow to India with a permanent position in a leading educational research institute it has been foreseen that it will open a fruitful collaboration between coordinator and IIF research fellow to investigate this area in depth in the near future.