Objective
The clinical use of engineered tissues depends upon the ability to direct cells to form specialized tissues with characteristic structural and mechanical properties. Functional implants generated in vitro would lead to the clinical use of engineered grafts tailored to (re)establish appropriate structure and function of lost or damaged native tissues. The clinical need for implants will be addressed in the specific context of the engineering of osteochondral plugs (cartilage surface at one end, bone at the o ther end, transient zone in between). The unifying hypothesis of the proposed research is that osteochondral composite grafts can be engineered in vitro by directed biophysical regulation of adult mesenchymal stem cell differentiation through biomimetic cu lture systems that provide gradients of regulatory molecules. We propose to set the differentiating stimuli through the controlled release of regulatory molecules from drug delivery systems, incorporated into a scaffold matrix. The objectives are (i) to de velop technologies for engineering stratified osteochondral tissues for reconstructions, and (ii) to improve our understanding of the mechanisms of adult cell growth and differentiation into complex tissues. The proposed application addresses a substantial clinical need of tissue-engineered reconstructions in osteochondral surfaces through the in vitro generation of functional stratified tissues, by biophysical regulation of human mesenchymal stem cells.This project fits in the Third Priority Thematic Area of Research and more precisely in the third topic of objective 3.4.1.1. Long-term interdisciplinary research into understanding phenomena, mastering processes and developing research tools. The objectives meet a socioeconomic demand in the EU and are expec ted to bring autologous and engineered tissues a step closer to clinical use.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences chemical sciences organic chemistry alcohols
- engineering and technology industrial biotechnology biomaterials
- medical and health sciences medical biotechnology implants
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ZUERICH
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.