Objective
Psychiatric disorders show a complex pattern of inheritance with genetic and environmental factors influencing disease risk. Despite the existence of numerous association studies aiming to identify genetic variants involved in these disorders, inconsistencies in replication studies are common and just a few examples of links between gene variants and psychiatric disorders have been accepted. Several factors may be underlying the failure on replication: difficulties on the definition of clinical phenotypes, existence of distinct disease incidences or disease susceptibility variants among populations and, finally, differences in Linkage Disequilibrium and allele frequencies because of diverse population history. Whole genome association studies (WGAS) are powerful methods to map disease genes, however, these expensive techniques have been unsuccessful for psychiatric disorders. An alternative approach could be the use of mapping by admixture linkage disequilibrium (MALD), an efficient and economical method to localize disease-causing variants between two historically separated populations. MALD has already been successful for identification of disease loci in African American populations and, similarly, it is hoped to be a powerful tool in Latin American populations. We propose the design of an admixture panel of SNPs to map susceptibility genes for psychiatric disorders, particularly substance use and attention-deficit hyperactivity disorders, by the analysis of native (Aymara) and recently admixed populations from Chile. Furthermore, we also plan to assess the repercussions that different genetic structures among populations may have on the interpretation of association studies and, finally, we will search for signals of natural selection and adaptation pinpointing potential genes affecting behavioural traits. This collaborative and interdisciplinary project will also focus on the anthropological and cultural implications of the research and results obtained.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- humanities history and archaeology history
- medical and health sciences clinical medicine psychiatry
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IOF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08002 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.