Objective
Animals and their organs become patterned as they grow. One of the most intriguing and challenging questions in developmental biology today is how patterning and growth are coordinated in time and space. Dpp, a member of TGF-β superfamily, with its ability to regulate both processes, serves as a paradigm to answer this question. Our first aim focuses on the logic of transcriptional regulation by Smad proteins, the nuclear effectors of the TGF-β pathways. The Drosophila Smad proteins, Mad and Medea, lead to activation of some target genes while inhibiting others. The putative cofactors required for Dpp-dependent activation have not been identified thus far. Here, I will test the hypothesis that T-box containing proteins, Dorsocross 1, 2, and 3, fulfill this function. In the second part, I aim to monitor Dpp signaling dynamics in vivo. I will fuse Dpp responsive elements to cDNA constructs that encode highly unstable versions of GFP or RFP allowing us to detect small and transient fluctuations in Dpp response. These experiments aim to achieve a detailed spatio-temporal analysis of the dynamics of Dpp signaling in growing tissues. Such in vivo studies will allow putting forward or excluding certain models of how Dpp exerts its multiple functions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4051 Basel
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.