Objective
Major or unipolar depression (UPD) is a major public health problem and cause economic negative consequences in industrialized countries (Hu,2006). Genetic studies offer an important route to understanding its causes. The inheritance of UPD is complex (Levinson,2005) and involves and inter-play of genetic and environmental factors (Farmer & McGuffin,2003;Cervilla et al,2007). There has been a small number of linkage scans. McGuffin and colleagues (2005) reported a genome-wide linkage scan in the first wave of the GlaxoSmith-Kline DeNt Study of 438 affected sib pairs with recurrent UPD. The aim of the proposed work is to investigate genetic overlap between Body Mass Index (BMI), diabetes type 2 ‘metabolic syndrome’ and recurrent UPD. Some recent studies support the hypothesis that there may be shared aetiological factors between recurrent UPD, obesity and physical disorders (Farmer et al,2008;Patten et al,2005). In the course of an ongoing genome-wide association (GWA) study of recurrent UPD, McGuffin and colleagues have collected a wealth of detailed data on chronic co-morbid physical diseases such as obesity, diabetes, heart disease and migraine on both depressive cases and controls. The availability of such information will enable the hypothesis of a genetic overlap between depression and elevated BMI to be explored comprehensively. Therefore we will 1) explore whether polymorphisms in known ‘obesity genes’ FTO and MC4R differ in frequency between depression cases and controls, 2) explore the entire dataset for novel genes associated with BMI, 3) search for SNP associations with the combined phenotype of high BMI/depression, 4) follow up the top 10 ‘hits’ with re-genotyping and/or deep sequencing. The study capitalises on several large case collections with closely comparable data and will use the most cost effective method of examining a large number of SNPs and CNVs at a time when similar studies on other common disorders are yielding exciting novel results
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences genetics genomes
- medical and health sciences health sciences nutrition obesity
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2R 2LS London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.