Objective
Currently circulating highly pathogenic avian influenza virus strains (H5N1) could cause a devastating pandemic if they became transmissible between humans. Thus understanding of the mechanisms whereby influenza virus adapts from avian to mammalian hosts is of great significance. Recent studies have highlighted the importance for transmissibility of mutations in the viral polymerase - a trimeric complex possessing activities essential for transcription and replication of the viral RNA. The mechanism of polymerase assembly and the host factors involved are not clear yet, nor are the molecular functions affected by the mutations related to avian-to-mammal transmission. To clarify these and to complement the extensive studies of atomic resolution structure of the polymerase and its host-specific variants performed in the Host laboratory, we propose to investigate in living cells the intracellular trafficking, assembly and interactions with host cell factors of the human and avian variants of the polymerase subunits. State-of-the-art two-colour fluorescence cross-correlation spectroscopy (FCCS) and confocal microscopy techniques will be used to monitor these phenomena in a non-invasive way. The project is inter-disciplinary as it combines advanced cell biophysics with structural and molecular biology in order to address a very topical issue in virology. The results will contribute to understanding of the relationships between the atomic structure of influenza virus polymerase and its function in the infected cell. New insight into adaptation of the influenza virus replication machinery to mammalian hosts can be used to elaborate new strategies for development of anti-viral compounds targeting polymerase or its interactions with host cell factors. Pursuing this multidisciplinary project in a prestigious international environment and learning state-of-the-art techniques will provide the applicant an excellent training for a future independent research position
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses influenza
- natural sciences biological sciences genetics mutation
- natural sciences physical sciences optics microscopy confocal microscopy
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69117 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.