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Content archived on 2024-06-18

Comparison of the gene regulatory programs of blood stem cells and megakaryocytes

Objective

Blood stem cells provide the constant supply of new blood cells throughout a person’s lifetime. Their transcriptional regulation, i.e. the fine tuning of which genes should be active at any given time, is critical for their normal function. Moreover, a large number of leukaemias arise, when this fine balance of gene activities is disturbed. However, very little is known about the molecular mechanisms responsible for setting the appropriate gene activities in blood stem cells. Transcription factors are responsible for controlling the activity of other genes and many of the transcription factors important for the normal function of blood stem cells are also active in the cell that forms blood platelets, the megakaryocyte. This proposal aims to compare the gene regulatory programs of blood stem cells and megakaryocytes. The focus will be on a triad of regulatory transcription factors: Gata2/Fli1/Scl, which have recently been shown to be essential for the development of blood cells during embryogenesis.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-IEF-2008
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
EU contribution
€ 170 733,61
Address
TRINITY LANE THE OLD SCHOOLS
CB2 1TN CAMBRIDGE
United Kingdom

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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