Objective
Phosphoinositide 3-kinases (PI3K) regulate many signalling events, having wide implications for cell biology in many cell types. Among the various catalytic subunit isoforms, p110 is expressed only in some leukocyte cells and was shown to have important potential for the regulation of immune responses. This PI3K isoform was shown to control development of allergic lung disease by affecting Th2 differentiation. Recently, p110 has been proposed to selectively control the production of the pro-allergic cytokine IL-6 in dendritic cells (DC), potentially explaining its importance in Th2 differentiation. We hypothesize in the current project that p110 is a much more central regulator of DC functions which controls most critical functions of these cells, like antigen uptake, processing, migration and T cell stimulatory and polarizing capacity. Also, as PI3Ks are in active balance with phosphatases such as PTEN, we propose that the tandem p110/PTEN, rather than p110 alone, regulates DC function. Therefore, one central theme of the project will be to dissect how p110/PTEN-derived signalling affects the functions of different subsets of DCs that now make up the DC family, as this might provide critical new insights into immunoregulation. For our studies, we will use specific pharmacological antagonists or gene deficient animals, and we will use the latest tools and methods of cellular immunology and molecular biology. A combination of in vivo and in vitro approaches will allow us to depict the implication of p110 in all critical functions of DCs. At the completion of this project, we will have clear insights into how DC function is molecularly controlled by p110 and we will have gained a better understanding of how the p110antagonists that are under clinical development might work to suppress inflammation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine immunology
- natural sciences biological sciences molecular biology
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IIF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9000 GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.