Objective
Lung cancer is the most lethal cancer in the world today. There are limited options for clinicians when treating patients, with only 10-15% of lung cancer patients surviving their malignancy. Despite the introduction of new chemotherapies, lung cancer survival is unchanged from thirty years ago. New ways of treating this disease are needed. We hypothesise that modified mesenchymal stem cells (MSCs) may be used to deliver magnetic nanoparticles through their engraftment, killing both tumour epithelium and tumour vasculature, while preserving normal tissue. We propose to introduce bio-compatible tailored magnetic nanoparticles into the MSCs to enable localised cellular-level sensing and heating while retaining the full viability and functionality of the MSCs. We will examine the kinetics of MSC engraftment and compare histological samples to in vivo quantification of engraftment using contrast-enhanced small animal magnetic resonance imaging (MRI) based on sensing the MRI signal of the introduced nanoparticles. MSCs will subsequently be locally heated by applying a time-varying electromagnetic field to induce heating of the nanoparticles (a process similar in principle to that used in microwave ovens) and consequent tumour destruction. MSC delivered therapy is particularly attractive. MSCs are easy to culture, expand and genetically manipulate. They are immuno-privileged, and also home preferentially to tumour tissues allowing systemic delivery to widespread tumour and metastases. As such they offer a uniquely bio-compatible, patient-derived therapeutic solution to the life-threatening disease of lung cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences electromagnetism and electronics electromagnetism
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences medical biotechnology cells technologies stem cells
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
W15 4BS London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.